An adolescent with sickle cell anaemia experiencing disease-related complications: priapism and leg ulcer - a management challenge

Vasconcelos, Alexandra; Prior, Ana Rita; Ferrão, Anabela; Morais, Anabela

doi:10.1136/bcr.11.2011.5146

Cited by 5 publications

(6 citation statements)

References 20 publications

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“…Varying incidence has been reported among different phenotypes and geographical area 1. The incidence rate of leg ulcers in the adult SCD patients is reported to be up to 75% 2,6,7. Prevalence is reported to be 8–10% in homozygous patients and more than 50% in patients living in the tropical areas 8.…”

Section: Introductionmentioning

confidence: 99%

<p>Mini review: leg ulcers - a secondary complication of sickle cell disease</p>

AlDallal¹

2019

IJGM

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Sickle cell disease (SCD) is a group of inherited blood disorders recognized by WHO as a major public health problem. It affects morbidity and mortality of the affected population considerably. Leg ulcer in the lower limbs is a hallmark feature of SCD. Meticulous physical examination, thorough history, laboratory tests, and imaging will lead to proper diagnosis and lead to proper treatment and management of the cases. Although newer treatment strategies have improved the prognostic outcome of SCD, leg ulcers still are a disabling and difficult to treat a complication of the condition. This mini review summarizes this common complication of SCD.

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Section: Introductionmentioning

confidence: 99%

<p>Mini review: leg ulcers - a secondary complication of sickle cell disease</p>

AlDallal¹

2019

IJGM

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“…While high fetal hemoglobin levels are arguably associated with decreased severity of leg ulcers, there have been multiple reports of leg ulcers arising due to hydroxyurea use, which showed improvement upon discontinuation of the drug. 3,5,12 One study has shown that hydroxyurea impairs the migration of angiogenic bodies; this may be the causative mechanism of leg ulcer …”

Section: Management Optionsmentioning

confidence: 99%

“…[2][3][4] Incidence of leg ulcers is highest among male adult patients from low socioeconomic backgrounds. 2,5,6 Ulcers in patients with SCD are considered a marker of disease severity, with problematic ulcers commonly occurring in association with pulmonary hypertension and priapism.…”

Section: Introductionmentioning

confidence: 99%

“…The article citing this was written in 1975 with one in seven ulcers healing and two showing improvement. 3,5,7,13 Local wound care is imperative for treatment of ulcers in patients with SCD. Patients are encouraged to keep ulcers clean, with proper cleansing of the wounds using soap and water, or normal saline solution.…”

mentioning

confidence: 99%

“…Debridement serves to cleanse the wound of its necrotic, senescent cells, inflammatory, and bacterial loads. [2][3][4] The surgical reconstructive options used for leg ulcers in patients with SCD are most commonly skin grafts, and less frequently regional/distant flaps. The advantages of skin grafts revolve around the ease of surgery, but skin grafts on leg ulcers often fail acutely or after healing, most probably due to the poor vascularity of the underlying ulcer bed, leading to ulcer recurrence.…”

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confidence: 99%

See 2 more Smart Citations

Leg ulcers in sickle cell patients: management challenges

Khatib¹,

Hayek²

2016

CWCMR

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Sickle cell disease is an autosomal recessive hemoglobinopathy caused by an amino acid substitution from glutamic acid to valine in the beta hemoglobin chain. One of the common symptoms occurring in sickle cell patients are leg ulcers, which are notoriously painful, difficult to treat, and frequently recurrent. These ulcers pose a therapeutic challenge with multiple modalities proposed for treatment, but with scarce evidence of efficacy of any single modality. Ulcer prevention, rigorous wound care, pain control, and surgery are the current mainstays of sickle cell leg ulcer treatment.

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Management of Sickle Cell Disease Complications Beyond Acute Chest Syndrome

Ogu¹,

Badamosi²,

Camacho³

et al. 2021

JBM

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Sickle cell disease results in numerous complications that can lead to significant morbidity and mortality. Amongst them, acute chest syndrome is the leading cause of mortality. As a result, most providers are in tune with this complication and well versed with management. As sickle cell patients now live longer, they face a multitude of other complications that if left unattended, can lead to significant morbidity and mortality as well. It is critical to look beyond acute chest syndrome and adopt a more comprehensive approach to the management of the sickle cell patient.

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An adolescent with sickle cell anaemia experiencing disease-related complications: priapism and leg ulcer - a management challenge

Cited by 5 publications

References 20 publications

<p>Mini review: leg ulcers - a secondary complication of sickle cell disease</p>

<p>Mini review: leg ulcers - a secondary complication of sickle cell disease</p>

Leg ulcers in sickle cell patients: management challenges

Management of Sickle Cell Disease Complications Beyond Acute Chest Syndrome

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