2022
DOI: 10.1016/j.molcel.2022.08.015
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An ADP-ribosyltransferase toxin kills bacterial cells by modifying structured non-coding RNAs

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Cited by 33 publications
(36 citation statements)
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“…One of the challenges associated with T6SS effector identification in P. aeruginosa is that all three T6SSs are expressed at low levels under standard laboratory growth conditions. However, the discovery that the H1‐, H2‐, and H3‐T6SS are all negatively regulated by the posttranscriptional regulator, rsmA , has greatly facilitated effector discovery efforts because deletion of this gene results in a P. aeruginosa strain with constitutively active T6SSs (Ahmad et al, 2019; Allsopp et al, 2017; Bullen et al, 2022).…”
Section: Introductionmentioning
confidence: 99%
“…One of the challenges associated with T6SS effector identification in P. aeruginosa is that all three T6SSs are expressed at low levels under standard laboratory growth conditions. However, the discovery that the H1‐, H2‐, and H3‐T6SS are all negatively regulated by the posttranscriptional regulator, rsmA , has greatly facilitated effector discovery efforts because deletion of this gene results in a P. aeruginosa strain with constitutively active T6SSs (Ahmad et al, 2019; Allsopp et al, 2017; Bullen et al, 2022).…”
Section: Introductionmentioning
confidence: 99%
“…It is found in the human pathogens Pseudomonas aeruginosa (Table S7), Klebsiella aerogenes , Salmonella enterica , Acinetobacter baumannii , and Cronobacter sakazakii and the plant pathogen Ralstonia solanacearum . The PT3 representative we validated from Ralstonia solanacearum (see below) shares weak amino acid sequence similarity (41% identity) with the C-terminal of the T6SS effector RhsP2 from Pseudomonas aeruginosa 31, 32 and likely these toxins belong to the same toxin superfamily. PT4 is found only in the Proteobacteria phylum including in the human pathogens Klebsiella aerogenes , K. pneumoniae , K. variicola , Yersinia pestis , Y. pseudotuberculosis , Serratia marcescens , Salmonella enterica , Cronobacter sakazakii and in the animal and plant pathogens Edwardsiella anguillarum , E. ictaluri , Photorhabdus luminescens , and Pantoea agglomerans .…”
Section: Resultsmentioning
confidence: 99%
“…Another RNA modifying toxin is RhsP2 from P . aeruginosa ( Bullen et al ., 2022 ). Interestingly, this enzyme displays the conserved residues Y-E and E from the two DTX and CTX ART families ( Bullen et al ., 2022 ).…”
Section: Adp-ribosyltransferasesmentioning
confidence: 99%
“…aeruginosa ( Bullen et al ., 2022 ). Interestingly, this enzyme displays the conserved residues Y-E and E from the two DTX and CTX ART families ( Bullen et al ., 2022 ). RhsP2 ADP-ribosylates a series of non-coding RNAs in target cells, including 4.5S rRNA, 6S rRNA, tRNAs, hindering multiple essential pathways ( Bullen et al ., 2022 ).…”
Section: Adp-ribosyltransferasesmentioning
confidence: 99%
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