An adult can still die of salicylate poisoning in France in 2008

Galbois, Arnaud; Ait‐Oufella, Hafid; Baudel, Jean-Luc; Maury, Éric

doi:10.1007/s00134-009-1537-x

Cited by 6 publications

(7 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Rationale Few studies have evaluated the diagnostic impact of the use of an algorithm in metabolic acidosis, so it is difficult to provide a well-argued answer to the question. It is always essential to collect data by clinical history taking and physical examination [33]. Apart from the exceptions mentioned below, the use of an algorithm could subsequently be used to investigate simple settings of acidosis [28].…”

Section: Areas Of Recommendationsmentioning

confidence: 99%

“…Apart from the exceptions mentioned below, the use of an algorithm could subsequently be used to investigate simple settings of acidosis [28]. However, it is important to know if there are artifacts [34] or atypical [35], complex [33], or misleading clinical pictures [30, 36]. Acetylsalicylic acid poisoning associates initial respiratory alkalosis with metabolic acidosis responsible for an increase in the anion gap which is only partly explained by the accumulation of acetylsalicylic acid [33].…”

Section: Areas Of Recommendationsmentioning

confidence: 99%

“…However, it is important to know if there are artifacts [34] or atypical [35], complex [33], or misleading clinical pictures [30, 36]. Acetylsalicylic acid poisoning associates initial respiratory alkalosis with metabolic acidosis responsible for an increase in the anion gap which is only partly explained by the accumulation of acetylsalicylic acid [33]. The increased anion gap acidosis seen in ethylene glycol poisoning is in part due to the accumulation of glycolic acid, which some laboratory analyzers misidentify as lactate [34, 37].…”

Section: Areas Of Recommendationsmentioning

confidence: 99%

See 2 more Smart Citations

Diagnosis and management of metabolic acidosis: guidelines from a French expert panel

Jung¹,

Martinez²,

Claessens³

et al. 2019

Ann. Intensive Care

Self Cite

View full text Add to dashboard Cite

Metabolic acidosis is a disorder frequently encountered in emergency medicine and intensive care medicine. As literature has been enriched with new data concerning the management of metabolic acidosis, the French Intensive Care Society (Société de Réanimation de Langue Française [SRLF]) and the French Emergency Medicine Society (Société Française de Médecine d’Urgence [SFMU]) have developed formalized recommendations from experts using the GRADE methodology. The fields of diagnostic strategy, patient assessment, and referral and therapeutic management were addressed and 29 recommendations were made: 4 recommendations were strong (Grade 1), 10 were weak (Grade 2), and 15 were experts’ opinions. A strong agreement from voting participants was obtained for all recommendations. The application of Henderson–Hasselbalch and Stewart methods for the diagnosis of the metabolic acidosis mechanism is discussed and a diagnostic algorithm is proposed. The use of ketosis and venous and capillary lactatemia is also treated. The value of pH, lactatemia, and its kinetics for the referral of patients in pre-hospital and emergency departments is considered. Finally, the modalities of insulin therapy during diabetic ketoacidosis, the indications for sodium bicarbonate infusion and extra-renal purification as well as the modalities of mechanical ventilation during severe metabolic acidosis are addressed in therapeutic management.

show abstract

Section: Areas Of Recommendationsmentioning

confidence: 99%

Section: Areas Of Recommendationsmentioning

confidence: 99%

Section: Areas Of Recommendationsmentioning

confidence: 99%

See 1 more Smart Citation

Diagnosis and management of metabolic acidosis: guidelines from a French expert panel

Jung¹,

Martinez²,

Claessens³

et al. 2019

Ann. Intensive Care

Self Cite

View full text Add to dashboard Cite

show abstract

“…Il est donc difficile de répondre à la question de façon argumentée. Le recueil des données de l'anamnèse et de l'examen clinique est toujours indispensable [35]. En dehors des exceptions citées ci-dessous, l'utilisation d'un algorithme pourrait permettre dans un second temps d'investiguer les tableaux simples d'acidose [30].…”

Section: Avis D'experts Argumentaireunclassified

Diagnostic et Prise en Charge de l’Acidose Métabolique Recommandations formalisées d’experts communes Société de réanimation de langue française (SRLF) – Société française de médecine d’urgence (SFMU)

Jung

Martinez

Claessens

et al. 2019

Ann. Fr. Med. Urgence

View full text Add to dashboard Cite

L’acidose métabolique est un trouble fréquemment rencontré en médecine d’urgence et en médecine intensive réanimation. La littérature s’étant enrichie de nouvelles données concernant la prise en charge de l’acidose métabolique, la Société de Réanimation de Langue Française (SRLF) et la Société Française de Médecine d’Urgence (SFMU) ont élaboré des recommandations formalisées d’experts selon la méthodologie GRADE. Les champs de la stratégie diagnostique, de l’orientation et de la prise en charge thérapeutique ont été traités et vingt-neuf recommandations ont été formulées : quatre recommandations fortes (Grade 1), dix recommandations faibles (Grade 2) et quinze avis d’experts. Toutes ont obtenu un accord fort. L’application des méthodes d’Henderson-Hasselbalch et de Stewart pour le diagnostic du mécanisme de l’acidose métabolique est discutée et un algorithme diagnostique est proposé. L’utilisation de la cétonémie et des lactatémies veineuse et capillaire est également traitée. L’intérêt du pH, de la lactatémie et de sa cinétique pour l’orientation des patients en pré-hospitalier et aux urgences est envisagé. Enfin, les modalités de l’insulinothérapie au cours de l’acidocétose diabétique, les indications de la perfusion de bicarbonate de sodium et de l’épuration extra-rénale ainsi que les modalités de la ventilation mécanique au cours des acidoses métaboliques sévères sont traitées dans la prise en charge thérapeutique.

show abstract

“…Although the overall mortality rate due to acetylsalicylic acid poisoning is low, it is potentially fatal. 1,2 Severe acetylsalicylic acid poisoning may cause metabolic acidosis, convulsions, coma, hyperpyrexia, pulmonary edema, and renal failure. 3 Rapid alkalinization by sodium bicarbonate is useful for decreasing the amount of acetylsalicylic acid crossing the blood-brain barrier and increasing renal clearance.…”

Section: Introductionmentioning

confidence: 99%

Treatment of lethal acetylsalicylic acid poisoning without hemodialysis

Ueno

Oda

Soeda

et al. 2014

Acute Medicine & Surgery

View full text Add to dashboard Cite

Case: A woman aged in her 20s ingested approximately 99 g acetylsalicylic acid, and was transported to our hospital 2 h later. She was lucid, but complained of hearing loss and tinnitus. We performed gastric lavage and gave her activated charcoal several times. We attempted to maintain the urinary pH at 7.5 and output above 100 mL/h while preparing for urgent hemodialysis.Outcome: It was revealed after discharge that the blood concentration of acetylsalicylic acid was 103.8 mg/dL on admission (lethal dose level) and had decreased to 35.4 mg/dL by the next morning. The half-life was 8.5 h. Conclusion:Hemodialysis is strongly recommended for patients who take a lethal dose of acetylsalicylic acid. However, by carefully evaluating the vital signs and urinary output and pH, while preparing for emergency hemodialysis, we consider that it is possible to treat acetylsalicylic acid poisoning by alkaline diuresis and critical supportive care.

show abstract

An adult can still die of salicylate poisoning in France in 2008

Cited by 6 publications

References 4 publications

Diagnosis and management of metabolic acidosis: guidelines from a French expert panel

Diagnosis and management of metabolic acidosis: guidelines from a French expert panel

Diagnostic et Prise en Charge de l’Acidose Métabolique Recommandations formalisées d’experts communes Société de réanimation de langue française (SRLF) – Société française de médecine d’urgence (SFMU)

Treatment of lethal acetylsalicylic acid poisoning without hemodialysis

Contact Info

Product

Resources

About