An adult with COVID-19 kawasaki-like syndrome and ocular manifestations

Abstract

Purpose The severe acute respiratory syndrome coronavirus-2 and its associated infection known as COVID-19 have resulted in a global pandemic. Ocular manifestations of COVID-19 are nonspecific and include hyperemia, chemosis, epiphora, secretions, and eyelid edema. There is a paucity in the literature regarding COVID-19 related inflammatory syndromes which may also include ocular manifestations. Observations In pediatric patients, conjunctivitis has been recently reported in association with a multisystem inflammatory condition related to COVID-19 that shares features with Kawasaki disease and toxic shock syndrome. We describe the clinical course of an adult patient with symptoms and signs consistent with a Kawasaki-like syndrome. Conclusions and Importance To our knowledge, this report may be the first case of a Kawasaki-like syndrome in an adult with COVID-19 infection.

The JANUS of chronic inflammatory and autoimmune diseases onset during COVID-19 – A systematic review of the literature

“… [ 213 ] 1 (non-confirmed) F 7 PIMS-TS IVIg, glucocorticoids, ASA Recovered [ 214 ] 3 (2 confirmed) 2 M 1 F 6y PIMS-TS 2 shock IVIg, ASA Recovered [ 215 ] 570 (565 confirmed) 316 M 254 F 8y MIS-C 202 shock 424 IVIg, 331 glucocorticoids, 309 ASA 10 Deaths 95 Coronary artery abnormalities [ 216 ] 30 (2 confirmed) 12 M 2 F 2y 22 complete KD, 8 atypical KD 30 IVIg, 14 IVIg + glucocorticoids, Recovered 2 Coronary artery aneurysms [ 217 ] 25 (17 confirmed) 15 M 10 F 12.5y MIS-C 23 IVIg, 20 glucocorticoids, 10 TCZ, 4 infliximab, 1 anakinra Recovered 7 Coronary artery abnormalities [ 218 ] 11 (all confirmed) 9 M 2 F 59m PIMS-TS, 5 shock N.A. 2 Deaths [ 219 ] 1 (confirmed) M 45y KD IVIg, TCZ, topical glucocorticoids Recovered [ 220 ...…”

Histopathological findings and clinicopathologic correlation in COVID-19: a systematic review

“…Furthermore, MIS-C has lower naïve CD4 + T cell and T follicular helper and increased central and effector memory subpopulations compared to KD [ 189 ]. MIS has also been reported in adults recently, although as a rare occurrence [ 190 – 192 ].…”

Clinical Characteristics of Multisystem Inflammatory Syndrome in Adults

“…In total, 449 relevant articles were identified, and 86 were selected for in-depth review; of these, 60 had data for patients with MIS-A. 2 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 Figure 1 summarizes...…”