2018
DOI: 10.1186/s12881-018-0702-x
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An African perspective on the genetic risk of chronic kidney disease: a systematic review

Abstract: BackgroundIndividuals of African ethnicity are disproportionately burdened with chronic kidney disease (CKD). However, despite the genetic link, genetic association studies of CKD in African populations are lacking.MethodsWe conducted a systematic review to critically evaluate the existing studies on CKD genetic risk inferred by polymorphism(s) amongst African populations in Africa. The study followed the HuGE handbook and PRISMA protocol. We included studies reporting on the association of polymorphism(s) wit… Show more

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Cited by 21 publications
(11 citation statements)
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References 56 publications
(111 reference statements)
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“…In this regard, there are relatively few ‘omics studies that focus on hypertension in the context of CKD in African populations ( Alicic et al, 2017 ). There was a single study with individuals from West Africa, highlighting the lack of ‘omics research in continental Africans ( Chen et al, 2007 ), despite many studies documenting the well-established genetic link to CKD in African Americans ( APOL1- associated nephropathy) ( George et al, 2018 ).…”
Section: Discussionmentioning
confidence: 99%
“…In this regard, there are relatively few ‘omics studies that focus on hypertension in the context of CKD in African populations ( Alicic et al, 2017 ). There was a single study with individuals from West Africa, highlighting the lack of ‘omics research in continental Africans ( Chen et al, 2007 ), despite many studies documenting the well-established genetic link to CKD in African Americans ( APOL1- associated nephropathy) ( George et al, 2018 ).…”
Section: Discussionmentioning
confidence: 99%
“…( 6 ) International studies also pointed out that the prevalence of CRF is four times higher in people of African ethnicity when compared to those of European ethnicity. ( 7 ) Something similar was found in the United States, where kidney disease predominantly affects African Americans. ( 8 ) The problem extends to kidney transplantation, a type of kidney replacement therapy that increases the quality of life of patients.…”
Section: Introductionmentioning
confidence: 61%
“…(29) Disease-associated variants and PRSs derived from these variants (identified by GWAS of European populations) frequently fail to replicate or perform well in non-European populations due to differences in allelic frequencies, linkage disequilibrium and haplotype structure, and confounding by environmental risk factors. (32) Genetic diversity between African ethnolinguistic groups is greater than the diversity between Europeans and Asians, which represent only a subset of African diversity. (33) A recent whole genome sequencing analysis of 426 individuals from 50 ethnolinguistic groups highlights the breadth of genetic diversity and complex patterns of admixture and genetic stratification in SSA, indicating that the development of pan-African PRSs for multifactorial complex diseases like CKD will be challenging.…”
Section: Most Common Forms Of Chronic Kidney Disease Show Polygenic Inheritancementioning
confidence: 99%