An Ag-loaded photoactive nano-metal organic framework as a promising biofilm treatment

Arenas‐Vivo, Ana; Amariei, Georgiana; Aguado, Sónia; Rosal, Roberto; Horcajada, Patricia

doi:10.1016/j.actbio.2019.08.011

Cited by 52 publications

(41 citation statements)

References 48 publications

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“…Bacterial adhesion structures were clearly observed for the lower concentration of [Ru(CO)2Cl2]n. However, with further increased concentration of [Ru(CO)2Cl2]n, the surfaces were almost free from bacteria under irradiation. ]n activity and due to destabilization of the bacterial wall or the impairment of the lipopolysaccharide interlocking structure, the bacteria become impaired (Ghosh et al, 2016;Arenas-Vivo et al, 2019;Baral et al, 2016). The present study indicates that the antimicrobial polymeric [Ru(CO)2Cl2]n possess a very high activity with 99.9% removal of bacteria with concentration under light irradiation at nanogram/mL.…”

Section: Antifouling Photo-bactericidal Activity Of Polymeric [Ru(co)2cl2]nmentioning

confidence: 62%

Polymeric ruthenium precursor as a photoactivated antimicrobial agent

Ghosh

Amariei

Mosquera

et al. 2021

Journal of Hazardous Materials

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Ruthenium coordination compounds have demonstrated a promising anticancer and antibacterial activity, but their poor water solubility and low stability under physiological conditions may limit their therapeutic applications. Physical encapsulation or covalent conjugation with polymers may overcome these drawbacks, but generally involve multistep reactions and purification processes. In this work, the antibacterial activity of the polymeric precursor dicarbonyldichlororuthenium (II) [Ru(CO)2Cl2]n has been studied against Escherichia coli and Staphylococcus aureus. This Ru-carbonyl precursor shows minimum inhibitory concentration at nanogram per millilitre, which renders it a novel antimicrobial polymer without any organic ligands. Besides, [Ru(CO)2Cl2]n antimicrobial activity is markedly boosted under photoirradiation, which can be ascribed to the enhanced generation of reactive oxygen species under UV irradiation. [Ru(CO)2Cl2]n has been able to inhibit bacterial growth via the disruption of bacterial membranes and triggering upregulation of stress responses as shown in microscopic measurements. The activity of polymeric ruthenium as an antibacterial material is significant even at 6.6 ng/mL while remaining biocompatible to the mammalian cells at much higher concentrations. This study proves that this simple precursor, [Ru(CO)2Cl2]n, can be used as an antimicrobial compound with high activity and a low toxicity profile in the context of need for new antimicrobial agents to fight bacterial infections.

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Section: Antifouling Photo-bactericidal Activity Of Polymeric [Ru(co)2cl2]nmentioning

confidence: 62%

Polymeric ruthenium precursor as a photoactivated antimicrobial agent

Ghosh

Amariei

Mosquera

et al. 2021

Journal of Hazardous Materials

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“…According to the characteristics of MOFs, the roles of MOFs in antibacterial applications have been divided into the above-mentioned four parts, as shown in Figure . The manifestations of antimicrobial effects over different materials are diversified, such as the bacterial inactivation and death, the removal of antibiotic-resistant genes, the inhibition of biofilm formation, and the biofilm eradication. − This may be attributed to the diversified antimicrobial actions resulting from the different roles of MOFs, such as cation transport interruption, diffusion-directed lipid-oxidation, direct interaction, photogenerated ROS formation, and membrane depolarization, leading to the bacterial cell damage and functional loss such as ion channel and cell membrane destruction, enzyme inactivation, protein denaturation, mitochondria, and DNA destruction. ,,,, …”

Section: Fundamentalsmentioning

confidence: 99%

Metal–Organic-Framework-Based Materials for Antimicrobial Applications

2021

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To address the serious threat of bacterial infection to public health, great efforts have been devoted to the development of antimicrobial agents for inhibiting bacterial growth, preventing biofilm formation, and sterilization. Very recently, metal–organic frameworks (MOFs) have emerged as promising materials for various antimicrobial applications owing to their different functions including the controlled/stimulated decomposition of components with bactericidal activity, strong interactions with bacterial membranes, and formation of photogenerated reactive oxygen species (ROS) as well as high loading and sustained releasing capacities for other antimicrobial materials. This review focuses on recent advances in the design, synthesis, and antimicrobial applications of MOF-based materials, which are classified by their roles as component-releasing (metal ions, ligands, or both), photocatalytic, and chelation antimicrobial agents as well as carriers or/and synergistic antimicrobial agents of other functional materials (antibiotics, enzymes, metals/metal oxides, carbon materials, etc.). The constituents, fundamental antimicrobial mechanisms, and evaluation of antimicrobial activities of these materials are highlighted to present the design principles of efficient MOF-based antimicrobial materials. The prospects and challenges in this research field are proposed.

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“…This is one of the most stimulating new expansions in nanoporous science, also known as porous coordination, hybrid organic-inorganic coordination networks. The MOFs have some unique properties that make it more prolific such as high porosity and high surface area, which are usually from 1,000 to 10,000 m 2 /g, which is higher than conventional porous materials (Arenas-Vivo et al, 2019). Metal organic frameworks extensively explored for drug delivery system in modern development due to excellent drug-loading capacity, informal functionalization, ideal biodegradability, and good biocompatibility.…”

Section: Metal Organic Frameworkmentioning

confidence: 99%

“…4 gal) MOF material, which was effectively used against pathogens and used as antioxidant carrier too. The Ag metal ions also got significant attention due to their remarkable properties especially as antimicrobial agent Arenas- Vivo et al (2019). studied the Ag-based MOF material and used against bacterial diseases and achieved significant results.…”

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confidence: 99%

Recent Advances in Metal Decorated Nanomaterials and Their Various Biological Applications: A Review

et al. 2020

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Nanoparticles (nanoparticles) have received much attention in biological application because of their unique physicochemical properties. The metal-and metal oxide-supported nanomaterials have shown significant therapeutic effect in medical science. The mechanisms related to the interaction of nanoparticles with animal and plant cells can be used to establish its significant role and to improve their activity in health and medical applications. Various attempts have been made to discuss the antibiotic resistance and antimicrobial activity of metal-supported nanoparticles. Despite all these developments, there is still a need to investigate their performance to overcome modern challenges. In this regard, the present review examines the role of various types of metal-supported nanomaterials in different areas such as antibacterial, antifungal, anticancer, and so on. Based on the significant ongoing research and applications, it is expected that metal-supported nanomaterials play an outstanding role not only in medical but also in other important areas.

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An Ag-loaded photoactive nano-metal organic framework as a promising biofilm treatment

Cited by 52 publications

References 48 publications

Polymeric ruthenium precursor as a photoactivated antimicrobial agent

Polymeric ruthenium precursor as a photoactivated antimicrobial agent

Metal–Organic-Framework-Based Materials for Antimicrobial Applications

Recent Advances in Metal Decorated Nanomaterials and Their Various Biological Applications: A Review

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