An agar–polyvinyl alcohol hydrogel loaded with tannic acid with efficient hemostatic and antibacterial capacity for wound dressing

Cheng, Chong; Peng, Xu; Xi, Linjie; Wan, Chenhao; Shi, Shengbao; Wang, Yuhang; Yu, Xixun

doi:10.1039/d2fo02251f

Cited by 28 publications

(11 citation statements)

References 53 publications

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“…The improvement of the mechanical properties of the XG-based composite hydrogels is also due to the presence of intermolecular hydrogen bonding between the functional groups of XG, PVA, and resveratrol, which reinforced the whole cryogel network. Similar results have also been reported for agar/PVA hydrogels loaded with tannic acid [ 54 ].…”

Section: Resultssupporting

confidence: 90%

Correlation between Mechanical and Morphological Properties of Polyphenol-Laden Xanthan Gum/Poly(vinyl alcohol) Composite Cryogels

Rǎschip¹,

Darie-Niță²,

Fifere³

et al. 2023

Gels

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This study aimed to evaluate the effect of the synthesis parameters and the incorporation of natural polyphenolic extract within hydrogel networks on the mechanical and morphological properties of physically cross-linked xanthan gum/poly(vinyl alcohol) (XG/PVA) composite hydrogels prepared by multiple cryo-structuration steps. In this context, the toughness, compressive strength, and viscoelasticity of polyphenol-loaded XG/PVA composite hydrogels in comparison with those of the neat polymer networks were investigated by uniaxial compression tests and steady and oscillatory measurements under small deformation conditions. The swelling behavior, the contact angle values, and the morphological features revealed by SEM and AFM analyses were well correlated with the uniaxial compression and rheological results. The compressive tests revealed an enhancement of the network rigidity by increasing the number of cryogenic cycles. On the other hand, tough and flexible polyphenol-loaded composite films were obtained for a weight ratio between XG and PVA of 1:1 and 10 v/v% polyphenol. The gel behavior was confirmed for all composite hydrogels, as the elastic modulus (G′) was significantly greater than the viscous modulus (G″) for the entire frequency range.

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Section: Resultssupporting

confidence: 90%

Correlation between Mechanical and Morphological Properties of Polyphenol-Laden Xanthan Gum/Poly(vinyl alcohol) Composite Cryogels

Rǎschip¹,

Darie-Niță²,

Fifere³

et al. 2023

Gels

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“…In previous research, NYS has shown broad‐spectrum fungicidal activity and effectiveness against some fungal infections resistant to Amphotericin B, making it a desirable compound in topical patches [40] . NYS release in addition to TA would greatly benefit in wound healing which is why TA was not washed from the hydrogel [41–44] …”

Section: Resultsmentioning

confidence: 99%

“…[40] NYS release in addition to TA would greatly benefit in wound healing which is why TA was not washed from the hydrogel. [41][42][43][44]…”

Section: Nystatin Release Kineticsmentioning

confidence: 99%

In Vitro Release Kinetics of Nystatin and Tannic Acid in Artificial Body Fluids from Hydrogels Prepared by Using Polyvinylpyrrolidone Crosslinked with Tannic Acid

Patel,

Lata,

Sharma

et al. 2023

ChemistrySelect

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Biocompatible hydrogels of polyvinylpyrrolidone (PVP) with tannic acid (TA) in the weight ratios of 1 : 0.70 (70 %)–1 : 0.60 (60 %) were prepared and loaded with the antifungal drug, nystatin (NYS). The hydrogel is expected to exhibit a two‐fold (anti‐bacterial and anti‐fungal) characteristics. Infrared spectroscopy (IR), viscometry and differential scanning calorimetry (DSC) were used to investigate interactions between PVP and TA. In vitro release kinetics of NYS in simulated body fluid (SBF) and sweat (SS) were studied using ultra‐violet spectroscopy (UV) and high‐performance liquid chromatography (HPLC). An increase in the glass transition temperature (Tg) of PVP accompanied with changes observed in the OH stretching, C=O and the C−O−C regions in the IR spectrum in dried PVP/TA hydrogel suggested physical crosslinking. The swelling of the hydrogels in distilled deionized water (DDW), SBF and SS decreased with increasing TA concentration and showed pH sensitivity. TA release followed the Korsmeyer‐Peppas kinetic model regardless of swelling media while NYS followed the Korsmeyer‐Peppas and Hixson‐Crowell cube root law in SS and SBF respectively. TA was active against Escherichia coli and Staphylococcus aureus while NYS against Candida albicans. A topical patch was prepared by adhering the drug loaded PVP/TA hydrogel onto silicone strips.

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“…Using the method of counting live cells, it was shown that the biomaterial containing two compounds with antibacterial activity—chitosan and tannic acid—caused complete inhibition of the growth of Gram-negative E. coli bacteria. Cheng et al [ 128 ] also incorporated tannic acid as an antibacterial agent into a PVA and agar-based hydrogel. In vitro tests proved that the biomaterial with the lowest tested concentration of TA (1%) revealed high antibacterial activity against S. aureus and E. coli .…”

Section: Antimicrobial Biomaterialsmentioning

confidence: 99%

Wound Dressing Modifications for Accelerated Healing of Infected Wounds

Vivcharenko

Trzaskowska

Przekora

2023

IJMS

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Infections that occur during wound healing involve the most frequent complications in the field of wound care which not only inhibit the whole process but also lead to non-healing wound formation. The diversity of the skin microbiota and the wound microenvironment can favor the occurrence of skin infections, contributing to an increased level of morbidity and even mortality. As a consequence, immediate effective treatment is required to prevent such pathological conditions. Antimicrobial agents loaded into wound dressings have turned out to be a great option to reduce wound colonization and improve the healing process. In this review paper, the influence of bacterial infections on the wound-healing phases and promising modifications of dressing materials for accelerated healing of infected wounds are discussed. The review paper mainly focuses on the novel findings on the use of antibiotics, nanoparticles, cationic organic agents, and plant-derived natural compounds (essential oils and their components, polyphenols, and curcumin) to develop antimicrobial wound dressings. The review article was prepared on the basis of scientific contributions retrieved from the PubMed database (supported with Google Scholar searching) over the last 5 years.

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An agar–polyvinyl alcohol hydrogel loaded with tannic acid with efficient hemostatic and antibacterial capacity for wound dressing

Abstract: Rapid hemostasis, antibacterial effect and promotion of wound healing are the most important functions that wound dressings need to have. In this work, we designed and prepared a hydrogel with...

Cited by 28 publications

References 53 publications

Correlation between Mechanical and Morphological Properties of Polyphenol-Laden Xanthan Gum/Poly(vinyl alcohol) Composite Cryogels

Correlation between Mechanical and Morphological Properties of Polyphenol-Laden Xanthan Gum/Poly(vinyl alcohol) Composite Cryogels

In Vitro Release Kinetics of Nystatin and Tannic Acid in Artificial Body Fluids from Hydrogels Prepared by Using Polyvinylpyrrolidone Crosslinked with Tannic Acid

Wound Dressing Modifications for Accelerated Healing of Infected Wounds

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