“…In recent years, agent-based models are extensively used in systems biology and immunology [ 30 , 31 ]. These models range from cellular and molecular aggregation [ 32 , 33 ], receptor–ligand interactions [ 34 , 35 , 36 ], signal transduction in bacteria [ 37 ], and cellular homeostasis in diseases such as multiple sclerosis [ 38 ] to immune responses against tumors [ 39 ]. However, there are no agent-based models studying T cell signaling and consequently TCR cooperativity, to the best of our knowledge.…”