An aggregation-induced emission dye-powered afterglow luminogen for tumor imaging

Xu, Yan; Yang, Wenjun; Yao, Defan; Bian, Kexin; Zeng, Weiwei; Li, Kai; Wang, Dengbin; Zhang, Bingbo

doi:10.1039/c9sc04901k

Cited by 53 publications

(32 citation statements)

References 67 publications

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“…In addition to the issue of penetration depth, the other problem with in vivo fluorescence imaging is the high background signal from healthy tissues. Recent advance of afterglow luminescent materials inspired the invention of afterglow luminescent AIE NPs, which provided a good solution to this problem, offering more precise imaging of tumour regions for image‐guided therapy . As illustrated in Figure a, AGL AIE NPs were prepared by loading an AIE PS, TPE‐Ph‐DCM, which can generate bright NIR emission and ROS, and an enol ether precursor of Schaap's 1,2‐dioxetane into an amphiphilic polymer.…”

Section: Biomedical Applications Of Aiegen Probesmentioning

confidence: 99%

Aggregation‐Induced Emission: Recent Advances in Materials and Biomedical Applications

Cai,

Liu

2020

Angewandte Chemie

116

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The concept of aggregation‐induced emission (AIE) has opened new opportunities in many research fields. Motivated by the unique feature of AIE fluorogens (AIEgens), during the past decade, many AIE molecular probes and AIE nanoparticle (NP) probes have been developed for sensing, imaging and theranostic applications with excellent performance outperforming conventional fluorescent probes. This Review summarizes the latest advancement of AIE molecular probes and AIE NP probes and their emerging biomedical applications. Special focus is to reveal how the AIE probes are evolved with the development of new multifunctional AIEgens, and how new strategies have been developed to overcome the limitations of traditional AIE probes for more translational applications via fluorescence imaging, photoacoustic imaging and image‐guided photodynamic/photothermal therapy. The outlook discusses the challenges and future opportunities for AIEgens to advance the biomedical field.

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Section: Biomedical Applications Of Aiegen Probesmentioning

confidence: 99%

Aggregation‐Induced Emission: Recent Advances in Materials and Biomedical Applications

Cai,

Liu

2020

Angewandte Chemie

116

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“…18,27,28 Many triphenylamine derivatives show good biocompatibility. [29][30][31][32] Recently single-component organic photodetectors with a relatively narrow responsivity spectrum based on p-conjugated donor-acceptor (D-A) molecules with a triphenylamine electron donor core have been described. 33 Similar molecules with absorption spectra being close to the photosensitivity response of photoreceptors (blue cones, rods, green cones, red cones) can be used for creating full colour retinal prosthesis devices.…”

Section: Introductionmentioning

confidence: 99%

Pixelated full-colour small molecule semiconductor devices towards artificial retinas

et al. 2021

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“…In brief, 2‐((5‐(4‐(diphenylamino)phenyl)thiophen‐2‐yl)methylene)malononitrile (an AIE dye, TTMN) is synthesized according to our previous report. [ 30 ] Then, the synthesized TTMN is encapsulated with an amphiphilic copolymer (DSPE‐mPEG 2000 ) and purified by ultrafiltration to obtain S‐AIE. [ 27 ] Guided by the fluorescence of AIE, SDT is precisely conducted on 4T1‐tumor‐bearing mice.…”

Section: Introductionmentioning

confidence: 99%

An Ultrasound‐Excitable Aggregation‐Induced Emission Dye for Enhanced Sonodynamic Therapy of Tumors

Zeng

Yang

et al. 2020

Adv Healthcare Materials

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Ultrasound (US)‐triggered sonodynamic therapy (SDT) can significantly solve the problem of tissue penetrability of light of photodynamic therapy (PDT) that has long vexed physicians in clinics. However, there is a great shortage of sonosensitizers for SDT. Currently, several photosensitizers and their derivatives have been reported for SDT but these dyes are usually quenched when aggregated due to aggregation‐caused quenching (ACQ) effect. In this work, aggregation‐induced emission (AIE) dye (TTMN) assembled nanoparticles (S‐AIE) are synthesized and employed as sonosensitizers for enhanced SDT due to the unique properties of the AIE dye and the deep tissue penetration of ultrasound. Results show that S‐AIE can generate potent singlet oxygen (1O2) under US irradiation to induce cancer cells apoptosis and clearly inhibit tumor growth in vitro and in vivo. In particular, the intrinsic fluorescence of AIE dye can guide the procedure of SDT. To the best of current knowledge, this is the first demonstration of AIE dyes being used as sonosensitizers for SDT and importantly, this work could inspire other more efficient AIE dyes for being used as sonosensitizers for SDT of deep‐seated tumors.

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An aggregation-induced emission dye-powered afterglow luminogen for tumor imaging

Abstract: An aggregation-induced emission (AIE) dye-powered afterglow luminogen has been designed for in vivo tumor imaging. The underlying afterglow mechanism can be described as a closed-loop of “photon–1O2–SP intermediates–photon”.

Cited by 53 publications

References 67 publications

Aggregation‐Induced Emission: Recent Advances in Materials and Biomedical Applications

Aggregation‐Induced Emission: Recent Advances in Materials and Biomedical Applications

Pixelated full-colour small molecule semiconductor devices towards artificial retinas

An Ultrasound‐Excitable Aggregation‐Induced Emission Dye for Enhanced Sonodynamic Therapy of Tumors

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