An Aggressive Case of Sinonasal Squamous Cell Carcinoma, Invasive to Bone, Arising Within Inverted Papilloma with Intracranial Extension: A Case Report

Jesus, Katherine de de Garcia; Gupta, Sorab; Hwang, Richard; Vigoda, Ivette; Cisneros, Oscar

doi:10.7759/cureus.4508

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…The involvement of adjacent structures leading to facial deformity or functional deficit is often a late presentation. 2 Among the available imaging techniques, Magnetic Resonance Imaging (MRI) is the preferred imaging technique to characterize masses owing to its superior soft tissue contrast resolution. However, the imaging features are often nonspecific and can also be misleading, for example malignant melanoma of the nasal cavity could appear as a benign polypoidal lesion on imaging, 3 convoluted cerebriform pattern although described for inverted papilloma can also be seen in malignant pathologies.…”

Section: Introductionmentioning

confidence: 99%

Differentiation of Benign From Malignant Sinonasal Masses Using Diffusion Weighted Imaging and Dynamic Contrast Enhanced Magnetic Resonance Imaging

Daga

Kumar

Pradhan

et al. 2021

Am J Rhinol�Allergy

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Background The sinonasal region is affected by a variety of neoplasms. A differentiation between benign and malignant masses is essential both for management and prognostication. Morphological analysis often does not allow this differentiation. Objectives This article aims to assess the value of advanced MRI (diffusion [DWI] and dynamic contrast enhanced MRI [DCE-MRI]) in differentiation of benign and malignant sinonasal masses. Methods This prospective study included 40 patients with sinonasal masses who underwent advanced MR on 3T MR scanner. The lesions were analyzed based on morphological characteristics, qualitative, quantitative diffusion parameters, and time signal intensity curves. Apparent diffusion coefficient (ADC) values were acquired using b values of 50 and 1000 s/mm2. The accuracy of DWI, DCE-MRI, and combined DWI/DCE-MRI in differentiating benign from malignant sinonasal masses were analyzed. Results Perineural extension and growth pattern of the tumor were the best morphological discriminators. Mean ADC values for benign and malignant lesions were 1.675 ± 0.561 and 0.903 ± 0.405 × 10−3 mm2/sec, ,respectively. ROC revealed that ADC cutoff value of 1.005 × 10−3 mm2/sec provided an accuracy of 92.5% in differentiating benign from malignant masses ( P value <.01). On excluding the benign vascular masses (Juvenile Nasopharyngeal Angiofibroma and hemangioma), the time signal intensity curve showed 78% accuracy ( P value <.001). The highest diagnostic performance was achieved by combining DWI and DCE-MRI (95% accuracy). Conclusion DWI has higher accuracy than DCE-MRI. Quantitative DWI is preferable over qualitative DWI. Accuracy of DCE-MRI can be increased by excluding vascular masses with characteristic imaging features. DWI and DCE-MRI have the highest accuracy when used in combination than either of them alone in differentiating benign from malignant sinonasal masses.

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Section: Introductionmentioning

confidence: 99%

Differentiation of Benign From Malignant Sinonasal Masses Using Diffusion Weighted Imaging and Dynamic Contrast Enhanced Magnetic Resonance Imaging

Daga

Kumar

Pradhan

et al. 2021

Am J Rhinol�Allergy

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A Case Report of Sinonasal Primary Squamous Cell Carcinoma

Karim,

Luhana

2024

Indian J Otolaryngol Head Neck Surg

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Clinical Assessment of Anatomic Origin Effect on the Clinical Outcomes in Primary Squamous Cell Carcinomas Affecting Nasoethmoidal Complex

Bangeennavar

Barbi

Nayan

et al. 2022

Journal of Pharmacy and Bioallied Sciences

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Background: Sinonasal squamous cell carcinomas (SCCs) present a great challenge in their diagnosis and management owing to their rapid growth, regional recurrence, local recurrence, and aggressive spread locally. Aims: The present clinical trial was conducted to evaluate anatomic subsites' impact on the outcomes concerning SCCs affecting ethmoid sinuses and nasal cavity. Materials and Methods: Medical records for tumor staging, tumor classification, grading (histologic) clinical features, symptoms, anatomic subsite, p16 results, treatment provided, and the Tumor-related outcomes were obtained for 28 subjects. Following staging and grading, p16 assays were evaluated along with disease-specific survival and disease-free survival. The collected data were subjected to the statistical evaluation and the results were formulated by keeping the level of significance at P < 0.05. Results: Origin was seen from nasal septum, nasal floor, lateral wall, ethmoid sinus, and edge of naris to mucocutaneous junction in 21.4% ( n = 6), 7.14% ( n = 2), 35.71% ( n = 10), 7.14% ( n = 2), and 28.57% ( n = 8) subjects, respectively. For tumor staging, Stages I, II, III, and IV tumors were seen in, respectively, 39.28% ( n = 11), 21.42% ( n = 6), 10.71% ( n = 3), and 28.57% ( n = 8) study subjects. Node status was N0, N1, N2, and N3 in 78.57% ( n = 22), 3.57% ( n = 1), 7.14% ( n = 2), and 10.71% ( n = 3) subjects. Carcinoma arising from nasal septum had statistically significant worse disease-specific survival compared to carcinomas arising from other sites ( P < 0.001). Conclusion: The present study concludes that anatomic subsites largely govern the outcomes and tumor behavior. Also, squamous cell carcinoma affecting the nasal septum is an aggressive tumor with more compromised outcomes and more lymph node involvement.

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An Aggressive Case of Sinonasal Squamous Cell Carcinoma, Invasive to Bone, Arising Within Inverted Papilloma with Intracranial Extension: A Case Report

Abstract: Garcia de de Jesus et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 3.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Cited by 3 publications

References 11 publications

Differentiation of Benign From Malignant Sinonasal Masses Using Diffusion Weighted Imaging and Dynamic Contrast Enhanced Magnetic Resonance Imaging

Differentiation of Benign From Malignant Sinonasal Masses Using Diffusion Weighted Imaging and Dynamic Contrast Enhanced Magnetic Resonance Imaging

A Case Report of Sinonasal Primary Squamous Cell Carcinoma

Clinical Assessment of Anatomic Origin Effect on the Clinical Outcomes in Primary Squamous Cell Carcinomas Affecting Nasoethmoidal Complex

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