An Aggressive Presentation of Merkel Cell Carcinoma: A Case Report

Abstract

Merkel cell carcinoma (MCC) is a rare malignant neuroendocrine tumor more common in immunosuppressed old patients. It is characterized by a high frequency of local recurrence, regional nodal metastasis, distant metastasis, and low survival rate. The diagnosis of MCC is challenging due to its rarity and can be clinically mistaken for other skin cancer. We report a case of locally advanced MCC of the left groin with aggressive behavior that was finally controlled with a combined treatment and we collected data from the literature to discuss the appropriate therapeutic algorithm for the management of this uncommon skin tumor.

Merkel cell carcinoma of an atypical presentation: A case report and literature review

“…Merkel cell carcinoma (MCC) is a rare and aggressive primary cutaneous neuroendocrine carcinoma [1]. It is characterized by a high frequency of local recurrence, regional nodal metastasis, distant metastasis, and a low survival rate [2]. Its incidence has increased over the last thirty years.…”

Merkel cell carcinoma on the right calf in association with chronic lymphocytic leukemia: A case report

“…Consequently, it needs combined therapeutic management. 1,6 This study aimed to present a rare case of MCC, on an unusual site, associated with chronic lymphocytic leukemia (CLL) and its prognosis.…”

“…In this regard, diagnostic management of these patients requires the entire body examination of the lymph nodes and all required laboratory tests or imaging to rule out differential diagnoses such as basal cell carcinoma (BCC), squamous cell carcinoma, adnexal tumor, amelanotic melanoma, epidermoid cysts, pyogenic granuloma, angiosarcoma, and lymphoma. Consequently, it needs combined therapeutic management 1,6 . This study aimed to present a rare case of MCC, on an unusual site, associated with chronic lymphocytic leukemia (CLL) and its prognosis.…”