The participation of young people in agriculture is crucial in generating job opportunities and fostering the growth of agri-food systems in developing countries, particularly in Africa. This study aims to provide an in-depth review of existing studies on young people’s perceptions and factors influencing their participation in agribusiness. Additionally, the study aims to investigate the impact of the skill training intervention on youth engagement in agribusiness. The study also identifies and analyzes the constraints that hindered their engagement. The PRISMA guideline was followed to analyze 57 studies across Sub-Saharan Africa. Studies published from 2012 to 2022 were retrieved from various digital libraries, such as Google Scholar, Emerald Insight, Taylor & Francis Online, Wiley Online Library, and Science Direct. The review findings highlight that many young people in Africa view agriculture as a profitable industry and a means of subsistence. However, it was also observed that there are divergent opinions regarding agribusiness among young individuals. Factors such as access to finance, education, skills training, perceived social support, and prior experience in farming emerged as critical determinants influencing their decision to engage in agribusiness. Moreover, the study reveals that skill training programs positively impact youth participation in agribusiness. These interventions enhance their skills, increasing productivity, income, and employment opportunities. Nevertheless, access to finance and other essential resources, such as land and extension support, were identified as significant barriers to the involvement of young people in agribusiness. In order to promote the advancement of agri-food systems in Africa through youth participation, youth policies must prioritize access to various resources, including but not limited to capital, education, skills training, land, extension support, social support, mentoring, and private-sector involvement.