An AIE-based self-assembled fluorescent probe for COX-2 imaging

Abstract

The first AIE-based fluorescent probe TPI-IMC was developed for imaging of cyclooxygenase-2 (COX-2) in normal cells and cancer cells.

When AIE meets enzymes

“…7a). 71 In this probe, the 4-(1,4,5-triphenyl-1 H -imidazol-2-yl) pyridine (TPI) is an AIE fluorophore. The IMC was chosen to act as the recognition group because it could specifically bind to the hydrophobic site of COX-2.…”

Evaluation of cyclooxygenase-2 fluctuation via a near-infrared fluorescent probe in idiopathic pulmonary fibrosis cell and mice models

“…[25][26][27][28][29][30] Therefore, we preferred designing a fluorescent probe in the NIR region for imaging. Until now, several fluorescent probes for COX-2 have been developed, [31][32][33][34][35] but the short excitation and emission wavelengths of the developed probes limit their application to a certain extent. Therefore, we designed a nearinfrared fluorescent probe Cy-COX to detect COX-2 changes in organisms during the process of pulmonary fibrosis.…”

Compression Effects on Structural Relaxation Process of Amorphous Indomethacin

“…This nonselective cyclooxygenase inhibitor is useful for treating joint diseases [4], headaches [5], and patent ductus arteriosus [6]. In addition, one can apply IMC to design smart probes for identifying cancer cells [7][8][9]. However, the commercial form of IMC exhibits poor aqueous solubility and low bioavailability [10].…”