The complexity of the supply chains and the uncertainties in the processes cause business to become more vulnerable in the face of disruptions. Pandemic situations such as COVID-19 cause sudden disruptions in supply chains, causing processes to be disrupted. Especially in multi-stakeholder supply chains, the importance of stakeholder communication, motivation, and regulations i.e. comes to the forefront in order to ensure the resilience of supply chains. As learned with the COVID-19 pandemic, vaccine supply chains are also one of the multi-stakeholder supply chains and are extremely vulnerable to disruptions. In COVID-19 times, the importance of vaccine supply chain management and the resilience in vaccine supply chains increased. To have more resilient vaccine supply chains, stakeholder engagement is an essential issue. Therefore, the Graph Theory Matrix Approach has been used to determine factors of stakeholder engagement in multi-stakeholder vaccine supply chains and to specify the relationships between the factors of project and stakeholder engagement in vaccine supply chains to increase resilience in disruption times. The aim of the study is to identify the factors of project and stakeholder engagement that are necessary to ensure the resilience of multi-stakeholder vaccine supply chains and not be affected by disruptions such as COVID-19 as it is today. As a result of the study, innovativeness of stakeholders is the most important factor of stakeholder engagement in vaccine supply chains.