“…Salvage surgery carries significant risks of mortality and morbidity with up to 45% of patients developing a significant complication, including delayed perineal healing for greater than 3 months [80]. For this reason, perineal reconstruction using autologous tissue may be required using methods such as rectus abdominis myocutaneous flaps, gluteal flaps, gracilis flaps or free latissimus dorsi flaps [82], which may reduce wound breakdown rates in the heavily irradiated tissues [83,84]. Salvage surgery can achieve 5-year survival ranging from 29 to 75% [81,83,[85][86][87].…”