An algorithmic approach to the diagnosis of NK and T cell lymphomas

Soo, Kai Ling; Shustik, David A; Yusoff, L.Z. Mohd; Tan, Leonard; Tan, Soo Yong

doi:10.1097/pat.0b013e32834bf5d2

Cited by 5 publications

(2 citation statements)

References 75 publications

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“…T-cell lymphomas are a heterogeneous group of lymphomas that can present with extensive skin and soft tissue necrosis, resembling an infectious process (Serra et al , 1998; Jia and Sun, 2004; Falagas et al , 2007). Misdiagnosis of T-cell lymphomas could explain the observed associations particularly as some cutaneous T-cell lymphomas are often difficult to diagnose in the early stages of disease (Serra et al , 1998; Falagas et al , 2007; Soo et al , 2011). However, the long latency period between infection and diagnosis suggests that misdiagnosis of T-cell lymphoma is unlikely to fully explain the observed associations, and further investigation by T-cell subtype may provide further insight.…”

Section: Discussionmentioning

confidence: 99%

Common infection-related conditions and risk of lymphoid malignancies in older individuals

et al. 2014

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Background:Chronic antigenic stimulation may initiate non-Hodgkin (NHL) and Hodgkin lymphoma (HL) development. Antecedent, infection-related conditions have been associated, but evidence by lymphoproliferative subtype is limited.Methods:From the US SEER-Medicare database, 44 191 NHL, 1832 HL and 200 000 population-based controls, frequency-matched to all SEER cancer cases, were selected. Logistic regression models, adjusted for potential confounders, compared infection-related conditions in controls with HL and NHL patients and by the NHL subtypes diffuse large B-cell, T-cell, follicular and marginal zone lymphoma (MZL). Stratification by race was undertaken.Results:Respiratory tract infections were broadly associated with NHL, particularly MZL. Skin infections were associated with a 15–28% increased risk of NHL and with most NHL subtypes, particularly cellulitis with T-cell lymphoma (OR 1.36, 95%CI 1.24–1.49). Only herpes zoster remained associated with HL following Bonferroni correction (OR 1.55, 95% CI 1.28–1.87). Gastrointestinal and urinary tract infections were not strongly associated with NHL or HL. In stratified analyses by race, sinusitis, pharyngitis, bronchitis and cellulitis showed stronger associations with total NHL in blacks than whites (P<0.001).Conclusions:Infections may contribute to the aetiologic pathway and/or be markers of underlying immune modulation. Precise elucidation of these mechanisms may provide important clues for understanding how immune disturbance contributes to lymphoma.

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Section: Discussionmentioning

confidence: 99%

Common infection-related conditions and risk of lymphoid malignancies in older individuals

et al. 2014

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“…Variant translocations will display membranous or cytoplasmic staining. 15 , 16 Based on these findings we reviewed the first bone marrow biopsy performing additional immunohistochemistry for the ALKc protein which revealed positivity in some of the CD4 + small lymphocytes as well as in rare dispersed previously unrecognized atypical large cells which also turned out to be CD30 + . This prompted a diagnosis of peripheral blood and bone marrow involvement by a small cell component of an ALK+ ALCL of the composite variant (showing common type features in the serosa) presenting in leukemic phase ( Figure 2 ).…”

Section: Case Reportmentioning

confidence: 99%