An all-graphdiyne electrochemiluminescence biosensor for the ultrasensitive detection of microRNA-21 based on target recycling with DNA cascade reaction for signal amplification

Lin, Yu; Wu, Jiawen; Wu, Yeyu; Ma, Rongxian; Zhou, Yuyi; Shi, Jinyue; Li, Mingxiang; Tan, Xuecai; Huang, Ke-Jing

doi:10.1039/d3an00146f

Cited by 2 publications

(1 citation statement)

References 34 publications

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“…Graphene oxide quantum dots (GDYO QDs) are a derivative of graphene (GDY) with good electrical conductivity and luminescence properties. Lin et al [95] constructed an ECL biosensor for the ultrasensitive determination of miRNA-21 based on GDYO QDs. The sensor utilized AuNPs/GDY as the electrode substrate material, which not only connected to the capture probe via Au-S bonds but also enhanced the conductivity of the electrode surface.…”

Section: Electrochemiluminescencementioning

confidence: 99%

MicroRNA Biosensors for Early Detection of Hepatocellular Carcinoma

Lin,

Wang,

Luo

et al. 2023

Chemosensors

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Hepatocellular carcinoma (HCC) is the main pathological type of liver cancer. Due to its insidious onset and the lack of specific early markers, HCC is often diagnosed at an advanced stage, and the survival rate of patients with partial liver resection is low. Non-coding RNAs (ncRNAs) have emerged as valuable biomarkers for HCC detection, with microRNAs (miRNAs) being a particularly relevant class of short ncRNAs. MiRNAs play a crucial role in gene expression regulation and can serve as biomarkers for early HCC detection. However, the detection of miRNAs poses a significant challenge due to their small molecular weight and low abundance. In recent years, biosensors utilizing electrochemical, optical, and electrochemiluminescent strategies have been developed to address the need for simple, rapid, highly specific, and sensitive miRNA detection. This paper reviews the recent advances in miRNA biosensors and discusses in detail the probe types, electrode materials, sensing strategies, linear ranges, and detection limits of the sensors. These studies are expected to enable early intervention and dynamic monitoring of tumor changes in HCC patients to improve their prognosis and survival status.

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Section: Electrochemiluminescencementioning

confidence: 99%