An altered fecal microbial profiling in rosacea patients compared to matched controls

Chen, Yi Ju; Lee, Wei Hsiang; Ho, H.P.; Tseng, Ching Hung; Wu, Chun Ying

doi:10.1016/j.jfma.2020.04.034

Cited by 34 publications

(34 citation statements)

References 39 publications

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“…The study of Chen et al demonstrated a reduction in the fecal microbial richness in rosacea patients as well as a distinct fecal microbial community. The altered microbial composition might be due to sulfur metabolism, cobalamin, and carbohydrate transport [277]. The microbiome might be a critical therapeutic target.…”

Section: Gut Microbiome and Diet Implications In Rosaceamentioning

confidence: 99%

Gut–Skin Axis: Current Knowledge of the Interrelationship between Microbial Dysbiosis and Skin Conditions

et al. 2021

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The microbiome plays an important role in a wide variety of skin disorders. Not only is the skin microbiome altered, but also surprisingly many skin diseases are accompanied by an altered gut microbiome. The microbiome is a key regulator for the immune system, as it aims to maintain homeostasis by communicating with tissues and organs in a bidirectional manner. Hence, dysbiosis in the skin and/or gut microbiome is associated with an altered immune response, promoting the development of skin diseases, such as atopic dermatitis, psoriasis, acne vulgaris, dandruff, and even skin cancer. Here, we focus on the associations between the microbiome, diet, metabolites, and immune responses in skin pathologies. This review describes an exhaustive list of common skin conditions with associated dysbiosis in the skin microbiome as well as the current body of evidence on gut microbiome dysbiosis, dietary links, and their interplay with skin conditions. An enhanced understanding of the local skin and gut microbiome including the underlying mechanisms is necessary to shed light on the microbial involvement in human skin diseases and to develop new therapeutic approaches.

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Section: Gut Microbiome and Diet Implications In Rosaceamentioning

confidence: 99%

Gut–Skin Axis: Current Knowledge of the Interrelationship between Microbial Dysbiosis and Skin Conditions

et al. 2021

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“…In contrast, Chen et al [38] observed a lower abundance of Acidaminococcus and Megasphaera genera in Taiwanese subjects (11 rosacea patients and 110 controls, 90.9% women). Lactobacillus, Hemophilus, Roseburia, and Clostridium genera were also less abundant in rosacea patients than in controls, whereas Rhabdochlamydia, CF231, Bifidobacterium, Sarcina, and Ruminococcus genera were significantly more abundant [38]. Therefore, differences between rosacea patients and healthy subjects were observed in both studies, although the results were discordant.…”

Section: Does the Gut Microbiota Play A Role In Rosacea?mentioning

confidence: 88%

“…Microbial 16S rRNA PCR amplification and sequencing have enabled us to analyze complex microbial communities at the taxonomic and phylogenetic levels. However, to our disappointment, results from microbial studies in rosacea patients have so far been discordant at the level of both the skin [18][19][20] and the gut [37,38]. It is especially difficult to interpret the findings from these studies because skin and gut microbial composition depends on numerous factors, including food, age, stress, and environment.…”

Section: Discussionmentioning

confidence: 98%

“…In the study by Nam et al [37] performed in Korean women (12 rosacea patients and 251 controls), bacteria from the Peptococcaceae family and the Methanobrevibacter genus were detected in control subjects but not in rosacea patients, whereas bacteria from the Acidaminococcus and Megasphaera genera were significantly more abundant in rosacea patients than in controls [37]. In contrast, Chen et al [38] observed a lower abundance of Acidaminococcus and Megasphaera genera in Taiwanese subjects (11 rosacea patients and 110 controls, 90.9% women). Lactobacillus, Hemophilus, Roseburia, and Clostridium genera were also less abundant in rosacea patients than in controls, whereas Rhabdochlamydia, CF231, Bifidobacterium, Sarcina, and Ruminococcus genera were significantly more abundant [38].…”

Section: Does the Gut Microbiota Play A Role In Rosacea?mentioning

confidence: 94%

“…However, [9,12]. The gut microbiota in rosacea patients was recently investigated in two Asian metagenomic studies [37,38]. In the study by Nam et al [37] performed in Korean women (12 rosacea patients and 251 controls), bacteria from the Peptococcaceae family and the Methanobrevibacter genus were detected in control subjects but not in rosacea patients, whereas bacteria from the Acidaminococcus and Megasphaera genera were significantly more abundant in rosacea patients than in controls [37].…”

Section: Does the Gut Microbiota Play A Role In Rosacea?mentioning

confidence: 99%

See 2 more Smart Citations

Microbiota in Rosacea

Kim

2020

Am J Clin Dermatol

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Rosacea is a complex facial skin condition associated with abnormal inflammation and vascular dysfunction. Next to the known trigger factors, the role of microbiota in the development and aggravation of rosacea continues to raise interest. Demodex folliculorum mites, Helicobacter pylori, Staphylococcus epidermidis, Chlamydia pneumoniae, and the Demodexassociated bacterium, Bacillus oleronius are microbes that have been linked with rosacea. However, the results of studies which assessed their involvement in the disease have been inconsistent and inconclusive. Microbiological research in many different disciplines exploded in recent years as methods to analyze complex microbial communities at the taxonomic and phylogenetic levels became available. Here, we provide an update on the microorganisms implicated in rosacea and review the potential pathogenic role of microbes in the development of rosacea. Key Points Microbes have long been suspected to play a role in rosacea. Better understanding of the microbiota and its role in rosacea pathophysiology may help determine the impact of microbial dysbiosis and host reactivity in rosacea populations. Deeper knowledge of microbe-host interactions in rosacea will allow targeted patient care and aid the development of innovative therapies.

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Lithocholic acid promotes rosacea-like skin inflammation via G protein-coupled bile acid receptor 1

Xiao

Chen

Peng

et al. 2022

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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An altered fecal microbial profiling in rosacea patients compared to matched controls

Cited by 34 publications

References 39 publications

Gut–Skin Axis: Current Knowledge of the Interrelationship between Microbial Dysbiosis and Skin Conditions

Gut–Skin Axis: Current Knowledge of the Interrelationship between Microbial Dysbiosis and Skin Conditions

Microbiota in Rosacea

Lithocholic acid promotes rosacea-like skin inflammation via G protein-coupled bile acid receptor 1

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