Abstract:A new and a facile route to the synthesis of imidazo[1,2-a]quinolines has been described via iodocyclization reaction of 2-allylaminoquinoline derivatives using I 2 -NaI reagent.
“…There are significant number of reports on the cyanation of aryl aldehydes for the synthesis of aryl nitriles in the presence of the toxic, explosive and expensive reagents and organic solvents . Therefore, it is very important to develop simple and green methods for the synthesis of aryl nitriles from cheap and non‐toxic materials inside the green media.…”
An efficient, inexpensive and simple methodology has been reported for the cyanation of aryl and heteroaryl aldehydes using in situ synthesized silver nanoparticles (Ag NPs) with the use of Crocus sativus L. aqueous extract as a reducing and stabilizing biomedia. Furthermore, stable and cheap silver precursor (AgNO 3 ) along with the non-toxic, efficient and inexpensive cyanide source K 4 [Fe(CN) 6 ] are used for this reaction. This system provides an alternative protocol to the existing methods for the synthesis of aryl and heteroaryl nitriles. All products were obtained in good to excellent yields under ligand-and organic solvent-free conditions. The fouriertransform infrared spectroscopy (FT-IR), Ultraviolet-visible spectroscopy (UV-Vis), X-ray powder diffraction (XRD) and transmission electron microscopy (TEM) techniques were used for the characterization of the biosynthesized Ag NPs.[a] Dr.
“…There are significant number of reports on the cyanation of aryl aldehydes for the synthesis of aryl nitriles in the presence of the toxic, explosive and expensive reagents and organic solvents . Therefore, it is very important to develop simple and green methods for the synthesis of aryl nitriles from cheap and non‐toxic materials inside the green media.…”
An efficient, inexpensive and simple methodology has been reported for the cyanation of aryl and heteroaryl aldehydes using in situ synthesized silver nanoparticles (Ag NPs) with the use of Crocus sativus L. aqueous extract as a reducing and stabilizing biomedia. Furthermore, stable and cheap silver precursor (AgNO 3 ) along with the non-toxic, efficient and inexpensive cyanide source K 4 [Fe(CN) 6 ] are used for this reaction. This system provides an alternative protocol to the existing methods for the synthesis of aryl and heteroaryl nitriles. All products were obtained in good to excellent yields under ligand-and organic solvent-free conditions. The fouriertransform infrared spectroscopy (FT-IR), Ultraviolet-visible spectroscopy (UV-Vis), X-ray powder diffraction (XRD) and transmission electron microscopy (TEM) techniques were used for the characterization of the biosynthesized Ag NPs.[a] Dr.
An Alternative Route to the Synthesis of Imidazo[1,2-a]quinolines Using I 2 -NaI Reagent. -(UPADHYAY, S.; CHANDRA, A.; SINGH, S.; SINGH*, R. M.; J. Heterocycl. Chem. 48 (2011) 5, 1202-1205, http://dx.
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