An alternative approach to prepare alginate/acemannan 3D architectures

Abstract

Current research has explored biomedical applications using polymers and compounds derived from plant sources. In the present work, the interactions between acemannan, the main polysaccharide of aloe vera leaves, and alginate, a marine origin polymer were investigated to design biomaterials. As a proof-of-concept, alginate/acemannan beads were produced through an extrusion dipping method followed by freeze-drying technique to form porous beads. Characterization data confirmed that the Ca 2+ presence in acemannan composition resulted in a stronger interaction between alginate and acemannan promoting gel formation and further the development of beads with a micro/nano roughness on their surface and heterogeneous porous formation in their interior. Results obtained until now suggest that the present approach represent a feasible and straightforward platform to design 3D biomaterial architectures for biomedical applications. Graphic abstract

Physico-mechanical and ex vivo analysis of aloe-alginate hydrogels for cervical cancer treatment

“…The stiffness of the 1:1 group was an order of magnitude lower compared to the 0:1 group, and was larger than the 1:0 group (which indicated no effect with the introduction of CaCl 2 ). 45,46 The 2:1 blended group had similar G′ values regardless of the solvent used. Least expected, G′ of the 2:1 group exhibited higher values compared to the 1:1 group in water, which we proposed was related to the strong interaction between the two molecules and the higher aloe content.…”

“…The weight ratio had a lesser affect. 45,46 Hydrogel precursor solutions were formed with water or SVF and exposed to 0.5M CaCl 2 to induce crosslinking. The CaCl 2 concentration was selected after analyzing preliminary gelation kinetics of the alginate hydrogels, showing time and rate of ionic crosslinking at 0.1, 0.5, and 1M CaCl 2 (data not shown).…”

Building Fucoidan/Agarose-Based Hydrogels as a Platform for the Development of Therapeutic Approaches against Diabetes

“…Molecules 2023, 28, x FOR PEER REVIEW 6 of 27 The prepared polysaccharide solutions were viscoelastic materials exhibiting solid and liquid characteristics. The storage (G ) and loss (G ) moduli refer to the elastic and viscous response of a given material to shear stress, respectively [49,50]. In Figure 2(B1,B2), the evaluation of the storage modulus as a function of temperature is shown for Aga hydrogels of different concentrations (3 and 5%) and AgaFu 3 and AgaFu 5 at different proportions (a (4:10), b (5:10), and c (7:10)).…”