An alternative index for evaluating AMU and anti-methicillin-resistant Staphylococcus aureus agent use: A study based on the National Database of Health Insurance Claims and Specific Health Checkups data of Japan

Mita, Yosuke; Inose, Ryo; Goto, Ryota; Kusama, Yoshiki; Koizumi, Ryuji; Yamasaki, Daisuke; Ishikane, Masahiro; Takao, Masaki; Ohmagari, Norio

doi:10.1016/j.jiac.2021.02.009

Cited by 6 publications

(8 citation statements)

References 14 publications

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“…However, the dose and the administration period depend on the patient’s background and type of infection. Therefore, we reported that Patients/1000 inhabitants/day (PID), based on the number of patients who were administered with antibiotics, is a more useful index for evaluating AMU in each region than DID or DOTID [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Search for Indexes to Evaluate Trends in Antibiotic Use in the Sub-Prefectural Regions Using the National Database of Health Insurance Claims and Specific Health Checkups of Japan

et al. 2022

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The evaluation indexes of antimicrobial use (AMU) in sub-prefectural regions have not been established because these regional units are susceptible to the effects of population inflows and outflows. We defined the difference in AMU calculated each year as a new evaluation index and compared the AMU of secondary medical areas with those already reported for Japan and each prefecture. Patients/1000 inhabitants/day (PID) for oral antibiotics in 2013 and 2016 were calculated using the National Database of Health Insurance Claims and Specific Health Checkups. ΔPID was defined as the difference between the PIDs in 2013 and 2016. Differences in AMUs for Japan and prefectures that have already been published were also calculated, and the concordance rate with ΔPID in each secondary medical area was evaluated. Antibiotics and age groups with less than 50% concordance between secondary medical area and previously reported AMU changes were observed. This revealed that even at the secondary medical area level, which is more detailed than the prefectural level, the AMU changes were not consistent. Therefore, in order to appropriately promote measures against antimicrobial resistance, we suggest the necessity of not only surveying AMU at the national or prefectural levels but also examining sub-prefectural trends in AMU.

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Section: Introductionmentioning

confidence: 99%

Search for Indexes to Evaluate Trends in Antibiotic Use in the Sub-Prefectural Regions Using the National Database of Health Insurance Claims and Specific Health Checkups of Japan

et al. 2022

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“…AMU is often studied using the insurance claims database and sales data (7,8). The National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB) is an insurance claim database that contains most of the available data in the national healthcare insurance system.…”

Section: Introductionmentioning

confidence: 99%

The Use of Topical Antibiotics Based on the National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB) Open Data in 2017

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The national action plan on antimicrobial resistance (AMR) in Japan emphasizes the importance of understanding antimicrobial use (AMU). Some studies have been conducted on oral and parenteral AMU in Japan. However, there are few studies on the use of topical antimicrobials, such as in dermatology and ophthalmology. Therefore, the purpose of this study was to investigate topical AMU in Japan. Data on AMU in dermatology and ophthalmology were obtained from the 2017 National Database of Health Insurance Claims and Specific Health Checkups of Japan Open Data. The number of dermatological products used was 58,396,530 in 2017. The proportion of betamethasone/gentamicin was 50.5% and that of gentamicin 16.7%, whereas that of the ingredient quantity in gentamicin was 7.8%. It was suggested that topical AMU should be evaluated by the number of products. The number of ophthalmological products used was 24,655,653 in 2017, and the proportion of quinolones was 95.9%. The high prescription rate of quinolones may cause an increase in quinolone resistance in the ophthalmologic field. Topical AMU, which is a potential "blind spot" in the measures against AMR, needs to be continuously monitored, together with systemic AMU.

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“…The National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB) contains information regarding the medical institutions where the drugs are prescribed. In addition, because information with respect to the administered dose, administration period, and number of patients to whom the drugs are being administered, can be obtained, the NDB is useful in evaluating AMU [5,6]. In addition, the NDB is considered a reliable data source for the evaluation of AMU because Japan has an established medical insurance system [5].…”

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confidence: 99%

“…In addition, the NDB is considered a reliable data source for the evaluation of AMU because Japan has an established medical insurance system [5]. Previously, we reported that the AMU index using the number of patients was less confusing and easier to calculate than an index that used the administered dose and period [6].…”

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The intended purpose and regional patterns of use of antibiotics for managing Clostridioides (Clostridium) difficile infections: An analysis of the National Database of Health Insurance Claims and Specific Health Checkups data of Japan

Inose

Kamimoto

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et al. 2022

Journal of Infection and Chemotherapy

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An alternative index for evaluating AMU and anti-methicillin-resistant Staphylococcus aureus agent use: A study based on the National Database of Health Insurance Claims and Specific Health Checkups data of Japan

Cited by 6 publications

References 14 publications

Search for Indexes to Evaluate Trends in Antibiotic Use in the Sub-Prefectural Regions Using the National Database of Health Insurance Claims and Specific Health Checkups of Japan

Search for Indexes to Evaluate Trends in Antibiotic Use in the Sub-Prefectural Regions Using the National Database of Health Insurance Claims and Specific Health Checkups of Japan

The Use of Topical Antibiotics Based on the National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB) Open Data in 2017

The intended purpose and regional patterns of use of antibiotics for managing Clostridioides (Clostridium) difficile infections: An analysis of the National Database of Health Insurance Claims and Specific Health Checkups data of Japan

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