An alternative synthetic strategy for (3R),(5R)-5-hydroxy-de-O-methyllasiodiplodin and its epimer

Vema, Venkata Naresh; Kumari, Y. Bharathi; Musulla, Sridhar; Addada, Rama Krishnam Raju; Alapati, Srinivasa Rao

doi:10.1016/j.tetlet.2019.03.007

Cited by 4 publications

(1 citation statement)

References 16 publications

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“…[111] Moreover, it shows antimicrobial properties. [112] (3R),(5R)-5-Hydroxy-de-Omethyl lasiodiplodin 67 comprise 12-membered macrolactone unit with two stereogenic centers (3R,5R) linked to the 1,3dihydroxybenzene ring. [113] A short total synthesis of (3R),(5R)-5-hydroxy-de-O-methyllasiodiplodin and its epimer have been provided from commercially accessible (R)-propylene oxide and Orsellinic acid as starting precursors.…”

Section: -Membered Macrolidesmentioning

confidence: 99%

Applications of Wittig Reaction in the Total Synthesis of Natural Macrolides

et al. 2020

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The Wittig reaction involves the synthesis of an alkene via the conversion of an aldehyde or ketone with the already generated ylide from a phosphonium salt. Significantly, when this important name reaction is employed the desired alkenes are constructed via a predictable manner, thus resultant particularly are useful in the total synthesis of natural products and synthetic complex organic compounds with definite geometric isomers, exhibiting diverse biological potencies. In this review we try to highlight the applications of the Wittig reaction as an efficient and attractive strategy in the total synthesis of macrolides from 2008 to 2020.

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Section: -Membered Macrolidesmentioning

confidence: 99%