An Ambiguous Phenomenon of Radiation and Drugs: Recall Reactions

Çaloğlu, Murat; Yurut-Caloglu, Vuslat; Cosar-Alas, Rusen; Saynak, Mert; Karagöl, Hakan; Uzal, Cem

doi:10.1159/000099632

Cited by 27 publications

(25 citation statements)

References 52 publications

(69 reference statements)

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“…They can range from mild erythema to marked desquamation 15 . Although radiation recall dermatitis is the most common type of radiation recall reaction, other organs can be involved as well, resulting in pneumonitis, esophagitis, colitis, mucositis, and myositis [2][3][4][5] .…”

Section: Discussionmentioning

confidence: 99%

Radiation Recall Dermatitis with Azithromycin

Vujovic

2010

Current Oncology

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Radiation recall is a well-known phenomenon that involves the "recall" of an acute inflammatory reaction in a previously irradiated region after administration of certain drugs. The most common type of radiation recall is radiation recall dermatitis, which involves the reoccurrence of an acute inflammatory skin reaction in previously irradiated skin. Most radiation recall reactions are attributable to chemotherapeutic agents. One previously reported case of radiation recall dermatitis occurred after administration of an antibiotic. The present case report is the second of radiation recall dermatitis involving an antibiotic: azithromycin.

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Section: Discussionmentioning

confidence: 99%

Radiation Recall Dermatitis with Azithromycin

Vujovic

2010

Current Oncology

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“…Chemotherapy can be administered sequentially when there is evidence of systemic progress [20]. To prevent major side effects, chemotherapy should not be applied at the same time as radiotherapy of the orbit [24]. Literature contains no reports of a successful monochemotherapy for treating retrobulbar metastases of breast cancer with acute clinical symptoms.…”

Section: Discussionmentioning

confidence: 99%

Palliative Radiotherapy of Retrobulbar Orbit Metastases due to Breast Cancer

Zwicker

Herfarth²,

Welzel³

et al. 2008

Onkologie

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Background: In breast cancer, the occurrence of retrobulbar metastases of the orbit is rare compared to intraocular metastases. The clinical symptoms are quite different. Impairment of vision, exophthalmus, double vision, vertigo, and pain reduce patients’ quality of life. Patients and Methods: The benefit of palliative irradiation of the orbit was researched retrospectively in 7 patients. This report also presents the first case in the literature of a breast cancer patient with bi-orbital enophthalmus caused by bilateral retrobulbar metastases that were successfully treated with radiotherapy. Irradiation was performed by photon or electron beams (20–50 Gy). Clinical restaging was done at the end of radiotherapy and 6 weeks thereafter. Results: After irradiation, 6 out of 7 patients showed a distinct clinical response with good palliation and no major side effects. Exophthalmus, pain, and vertigo were significantly reduced in all cases. Double vision disappeared in 3 out of 4 patients, eye muscle paralysis in 5 out of 6 patients. The median overall survival after irradiation of the orbit was 7.3 months. Conclusion: Palliative radiotherapy of retrobulbar metastases of breast cancer is very effective in reducing acute clinical symptoms and increasing quality of life. Nonetheless, patients have a poor prognosis.

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“…The reaction is associated with the dose, the type of drug used and the sequence of time between radiation and the use of chemotherapy. 35 Toxicity may be additive or supra-additive (synergic). In supra-additive toxicity, the reaction is greater than that of the sum of each one of the types of treatment alone.…”

Section: Exacerbation Of Radiationmentioning

confidence: 99%

Reações tegumentares adversas relacionadas aos agentes antineoplásicos: parte II

Criado

Brandt

Moure

et al. 2010

An. Bras. Dermatol.

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Events and reactions involving chemotherapy are common in clinical oncology. Chemotherapeutic agents are widely used in therapy. Side effects range from the common to the rare and may be confused with other mucocutaneous manifestations resulting from the oncological treatment. The objective of this paper was to present data on skin reactions to chemotherapy, particularly those cases in which the dermatologist is requested to issue a report and asked to comment on the safety and viability of readministration of a specific drug. The authors describe aspects associated with these events, presenting a detailed analysis of each one of them. Keywords: Chemotherapy, adjuvant ; Drug therapy; Drug therapy, combination; Skin; Skin abnormalities; Skin pigmentation Resumo:Os eventos e reações envolvendo quimioterapia são frequentes na prática oncológica. Agentes quimioterápicos são uma modalidade de tratamento amplamente utilizada. Efeitos colaterais podem variar de frequência e também ser confundidos com outras manifestações tegumentares do tratamento oncológico. Este artigo objetiva expor as informações sobre reações cutâneas à quimioterapia, em especial, aqueles para os quais o dermatologista é requisitado a emitir parecer e a comentar sobre a segurança e a viabilidade da readministração de uma droga específica. Os autores descrevem os aspectos associados a esses eventos, fazendo uma análise detalhada de cada um deles.

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An Ambiguous Phenomenon of Radiation and Drugs: Recall Reactions

Cited by 27 publications

References 52 publications

Radiation Recall Dermatitis with Azithromycin

Radiation Recall Dermatitis with Azithromycin

Palliative Radiotherapy of Retrobulbar Orbit Metastases due to Breast Cancer

Reações tegumentares adversas relacionadas aos agentes antineoplásicos: parte II

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