Study design: Retrospective. Objective: To evaluate the safety and e cacy of the tension-free vaginal tape (TVT) for the treatment of stress incontinence in females with neuropathic bladders. Setting: London Spinal Injuries Unit, Stanmore & Institute of Urology, London, UK. Methods: Twelve women (mean age 53.3 years; range 41 ± 80 years) with neuropathic bladder dysfunction and stress urinary incontinence were treated with tension-free vaginal tape (TVT) between November 1997 and December 2000. The group consisted of women with: (i) traumatic spinal cord injuries (n=3); (ii) post lumbar spinal surgery (n=6); (iii) spinal stenosis (n=3). Four of the 12 patients had previously failed surgery for stress incontinence. All patients underwent pre-and post-TVT evaluation with video-urodynamic studies. Results: Mean follow-up was 27.1 months (range 17 ± 54 months). Three patients were voiding spontaneously (stress voiding) before surgery and continued to do so post-operatively. The remaining 9 were performing clean intermittent self-catheterisation before the insertion of TVT and continued to do so after the surgery. At follow up 10 patients (83.3%) were dry. The procedure failed in one patient and the other complained of mild leakage, but she reported a decrease in the number of pads used. One patient developed detrusor hyperre¯exia on postoperative video-urodynamics but there was no evidence of stress incontinence. One patient had a bladder perforation on insertion of TVT, managed successfully with extended use of a urethral catheter post-operatively. Three patients developed post-operative urinary tract infection successfully treated with oral antibiotics. Conclusions: Tension-free vaginal tape insertion is minimally invasive, safe and e ective for the treatment of stress incontinence in females with bladder neuropathy with intrinsic sphincter de®ciency. Previous surgery for incontinence did not a ect post-operative complications or outcome.