An amelanotic choroidal melanoma arising in a young man with tattoo-associated sarcoidosis

Berkowitz, Sean T.; Brock, Anderson L; Reichstein, David

doi:10.1016/j.ajoc.2020.100655

Cited by 5 publications

(6 citation statements)

References 28 publications

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“…Herbort described four different ICGA patterns in choroidal S [170,171]. OCT combined with EDI and combined depth imaging (CDI) and enhanced vitreous imaging (EVI) allows us to grade the intensity of vitreitis, as well as monitor and follow-up CME and subretinal fluid [172][173][174][175][176][177][178][179][180][181][182][183][184][185].…”

Section: Ocular Diagnostic Proceduresmentioning

confidence: 99%

“…Granulomas are seen as homogeneous, hyporeflective lesions with well-defined edges in a relatively thinner choriocapillary (thanks to their higher density being non-caseating in nature). Choroidal thickening is seen in posterior scleritis together with a serous retinal detachment [176][177][178][179][180][181][182][183] (Figure 10). imaging (EVI) allows us to grade the intensity of vitreitis, as well as monitor and followup CME and subretinal fluid [172][173][174][175][176][177][178][179][180][181][182][183][184][185].…”

Section: Ocular Diagnostic Proceduresmentioning

confidence: 99%

“…Choroidal thickening is seen in posterior scleritis together with a serous retinal detachment [176][177][178][179][180][181][182][183] (Figure 10). imaging (EVI) allows us to grade the intensity of vitreitis, as well as monitor and followup CME and subretinal fluid [172][173][174][175][176][177][178][179][180][181][182][183][184][185].…”

Section: Ocular Diagnostic Proceduresmentioning

confidence: 99%

“…Granulomas are seen as homogeneous, hyporeflective lesions with well-defined edges in a relatively thinner choriocapillary (thanks to their higher density being non-caseating in nature). Choroidal thickening is seen in posterior scleritis together with a serous retinal detachment [176][177][178][179][180][181][182][183] (Figure 10). Parrulli demonstrated that both EDI-OCT and ICGA are useful in evaluating choroidal granulomatous lesions.…”

Section: Ocular Diagnostic Proceduresmentioning

confidence: 99%

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Sarcoid Uveitis: An Intriguing Challenger

Allegri¹,

Olivari²,

Rissotto

et al. 2022

Medicina

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The purpose of our work is to describe the actual knowledge concerning etiopathogenesis, clinical manifestations, diagnostic procedures, complications and therapy of ocular sarcoidosis (OS). The study is based on a recent literature review and on the experience of our tertiary referral center. Data were retrospectively analyzed from the electronic medical records of 235 patients (461 eyes) suffering from a biopsy-proven ocular sarcoidosis. Middle-aged females presenting bilateral ocular involvement are mainly affected; eye involvement at onset is present in one-third of subjects. Uveitis subtype presentation ranges widely among different studies: panuveitis and multiple chorioretinal granulomas, retinal segmental vasculitis, intermediate uveitis and vitreitis, anterior uveitis with granulomatous mutton-fat keratic precipitates, iris nodules, and synechiae are the main ocular features. The most important complications are cataract, glaucoma, cystoid macular edema (CME), and epiretinal membrane. Therapy is based on the disease localization and the severity of systemic or ocular involvement. Local, intravitreal, or systemic steroids are the mainstay of treatment; refractory or partially responsive disease has to be treated with conventional and biologic immunosuppressants. In conclusion, we summarize the current knowledge and assessment of ophthalmological inflammatory manifestations (mainly uveitis) of OS, which permit an early diagnostic assay and a prompt treatment.

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Section: Ocular Diagnostic Proceduresmentioning

confidence: 99%

Section: Ocular Diagnostic Proceduresmentioning

confidence: 99%

Section: Ocular Diagnostic Proceduresmentioning

confidence: 99%

“…Granulomas are seen as homogeneous, hyporeflective lesions with well-defined edges in a relatively thinner choriocapillary (thanks to their higher density being non-caseating in nature). Choroidal thickening is seen in posterior scleritis together with a serous retinal detachment [176][177][178][179][180][181][182][183] (Figure 10). Parrulli demonstrated that both EDI-OCT and ICGA are useful in evaluating choroidal granulomatous lesions.…”

Section: Ocular Diagnostic Proceduresmentioning

confidence: 99%

See 2 more Smart Citations

Sarcoid Uveitis: An Intriguing Challenger

Allegri¹,

Olivari²,

Rissotto

et al. 2022

Medicina

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“…While the diagnosis of a pigmented uveal melanoma based on the eye fundus examination is not problematic in everyday practice, an amelanotic tumour, especially a small one, can be quite challenging. Nonpigmented uveal melanomas should be differentiated from other intraocular lesions, both malignant and benign such as: amelanotic nevus, metastasis, hemangioma, peripheral exudative hemorrhagic chorioretinopathy, sclerochoroidal calcification, osteoma, granuloma, lymphoma, solitary idiopathic choroiditis [ 29 , 30 ]. Fortunately, today, in doubtful cases, ultrasound and often optical coherence tomography (OCT) provide information for the correct diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Amelanotic Uveal Melanomas Evaluated by Indirect Ophthalmoscopy Reveal Better Long-Term Prognosis Than Pigmented Primary Tumours—A Single Centre Experience

Markiewicz

Donizy

Nowak³

et al. 2022

Cancers

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(1) Background: There is a constant search for new prognostic factors that would allow us to accurately determine the prognosis, select the type of treatment, and monitor the patient diagnosed with uveal melanoma in a minimally invasive and easily accessible way. Therefore, we decided to evaluate the prognostic role of its pigmentation in a clinical assessment. (2) Methods: The pigmentation of 154 uveal melanomas was assessed by indirect ophthalmoscopy. Two groups of tumours were identified: amelanotic and pigmented. The statistical relationships between these two groups and clinical, pathological parameters and the long-term survival rate were analyzed. (3) Results: There were 16.9% amelanotic tumours among all and they occurred in younger patients (p = 0.022). In pigmented melanomas, unfavourable prognostic features such as: epithelioid cells (p = 0.0013), extrascleral extension (p = 0.027), macronucleoli (p = 0.0065), and the absence of BAP1 expression (p = 0.029) were statistically more frequently observed. Kaplan–Meier analysis demonstrated significantly better overall (p = 0.017) and disease-free (p < 0.001) survival rates for patients with amelanotic tumours. However, this relationship was statistically significant for lower stage tumours (AJCC stage II), and was not present in larger and more advanced stages (AJCC stage III). (4) Conclusions: The results obtained suggested that the presence of pigmentation in uveal melanoma by indirect ophthalmoscopy was associated with a worse prognosis, compared to amelanotic lesions. These findings could be useful in the choice of therapeutic and follow-up options in the future.

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Tattoos and Risk of Hematologic Cancer: A Population‐Based Case–Control Study in Utah

McCarty,

Trabert,

Kriebel

et al. 2024

Cancer Medicine

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BackgroundApproximately one‐third of US adults have a tattoo, and the prevalence is increasing. Tattooing can result in long‐term exposure to carcinogens and inflammatory and immune responses.MethodsWe examined tattooing and risk of hematologic cancers in a population‐based case–control study with 820 cases diagnosed 2019–2021 and 8200 frequency‐matched controls, ages 18–79 years. We calculated odds ratios (OR) and 95% confidence intervals (CI) using multivariable‐adjusted logistic regression models.ResultsThe prevalence of tattooing was 22% among Hodgkin lymphoma (HL) cases, 11% among non‐Hodgkin lymphoma (NHL) cases, 16% among myeloid neoplasm cases, and 15% among controls. Though there were no clear patterns of associations between ever receiving a tattoo and risk of HL, NHL, or myeloid neoplasms overall, in analyses restricted to ages 20–60 years, ever receiving a tattoo (OR 2.06 [95% CI 1.01, 4.20]) and receiving a tattoo 10+ years prior (OR 2.64 [95% CI 1.23, 5.68]) were associated with an aggregated group of rarer mature B‐cell NHLs. We also observed elevated risks for a 10+ year latency for myelodysplastic syndromes and chronic myeloid leukemia (OR 1.48 [95% CI 0.40, 5.41], and OR 1.24 [95% CI 0.45, 3.43], respectively).ConclusionsThough estimates were imprecise, we found some suggestive evidence that tattooing may be associated with an increased risk of certain hematologic cancer subtypes. With an estimated 46% prevalence of tattooing in US individuals ages 30–49, additional studies are needed to understand the degree to which these exposures may be associated with hematologic cancer risk.

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An amelanotic choroidal melanoma arising in a young man with tattoo-associated sarcoidosis

Cited by 5 publications

References 28 publications

Sarcoid Uveitis: An Intriguing Challenger

Sarcoid Uveitis: An Intriguing Challenger

Amelanotic Uveal Melanomas Evaluated by Indirect Ophthalmoscopy Reveal Better Long-Term Prognosis Than Pigmented Primary Tumours—A Single Centre Experience

Tattoos and Risk of Hematologic Cancer: A Population‐Based Case–Control Study in Utah

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