An amperometric glucose biosensor based on a MnO<sub>2</sub>/graphene composite modified electrode

Liu, Yuge; Zhang, Xiumei; He, Dongning; Ma, Feiyue; Fu, Qiong; Hu, Yun Hang

doi:10.1039/c6ra02680j

Cited by 48 publications

(19 citation statements)

References 59 publications

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“…The sensitivity and LOD of the fabricated electrode are compared to various electrodes as shown in Table II. 11,18,28,29,[53][54][55][56][57][58] Most of the electrodes in the review have high sensitivity and good LOD as they used thick GO prepared by a modified Hummers method. Our electrode shows sensitivity and LOD similar to results by Palanisamy et al 18 which used thick GO hybridized with MWCNT and supported by glassy carbon electrode (GCE) that demonstrated high thermodynamic surface adsorption 59 and specific thermodynamics adsorption and redox reduction mechanism with GOx.…”

Section: Resultsmentioning

confidence: 99%

Functionalization of CVD Grown Graphene with Downstream Oxygen Plasma Treatment for Glucose Sensors

Hadish

Jou

Huang

et al. 2017

J. Electrochem. Soc.

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The development of graphene-based devices requires control over the functionalization and modification of the graphene surface. We studied the modification of the monolayer graphene surface with downstream oxygen plasma treatment to form graphene oxide (GO) for use in glucose biosensors. Amperometric and voltammetric methods were applied to GO for glucose oxidase (GOx) immobilization with a simultaneous reduction of GO to reduce graphene oxide. The fabricated glucose sensor shows a sensitivity of 0.118 μA mM −1 cm −2 and a detection limit of 0.0526 mM of glucose. This method provides fast and simultaneous immobilization of GOx and reduction of GO, and can be used in the fabrication of other electrochemical biosensors. Glucose oxidase has been recognized as an enzyme for monitoring glucose. In amperometric biosensors for glucose detection, GOx is immobilized on a nanomaterial surface and catalytically oxidizes glucose for high sensitivity and selectivity.9-11 However, enzyme immobilization is complicated by poor electrical communication of the active sites of the enzyme and the electrode surface, and by enzyme leaching. [12][13][14][15] Recently, graphene has been used to modify biosensors, offering advantages for enzyme immobilization on graphene surfaces. [16][17][18] Pristine graphene (PrG), a monolayer structure composed of one-atom thick two-dimensional honeycomb lattices of sp 2 carbon atoms, has extraordinary properties such as high intrinsic mobility and excellent thermal and electrical conductivity. [19][20][21][22] Although the bulk properties of graphene are very promising for a variety of applications, the development of graphene-based devices requires great control over the functionalization and modification of the graphene surface. Graphene oxide (GO) is one branch of functionalized graphene. GO is typically covalently functionalized with hydroxyl, epoxy, carbonyl, and carboxyl groups on its basal planes and at its edges, 23 resulting in a hybrid structure comprising a mixture of sp 2 and sp 3 hybridized carbon atoms. 24 GO sheets synthesized from graphite powders by the modified Hummers method 25 have been coated on carbon and Pt electrodes and used to immobilize GOx to develop glucose sensors. [26][27][28][29] On the other hand, monolayer graphene has been fabricated by chemical vapor deposition (CVD) on Cu and Ni substrates then transferred to other substrates for chemical and gas sensors. [30][31][32] Monolayer graphene has also been utilized for glucose sensor after immobilizing GOx to its surface through linker molecules. 33,34 With the aid of lithography and plasma etch techniques, monolayer-graphene-based devices can be patterned into arrays 32 and integrated with Si microelectronics technology. 35,36 In this work we synthesized GO from monolayer graphene by a downstream oxygen plasma. 37,38 The plasma-assisted technique has the advantages of short treatment time, an environmentally friendly manufacturing process, and the generation of numerous active species. 39 The immobilization of GOx en...

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Section: Resultsmentioning

confidence: 99%

Functionalization of CVD Grown Graphene with Downstream Oxygen Plasma Treatment for Glucose Sensors

Hadish

Jou

Huang

et al. 2017

J. Electrochem. Soc.

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“…Among them, MnO 2 had attracted much focus because of its low cost, good for easy synthesis, and so on. [110] Among some kinds of MnO 2 , particularly, polymorphs, α-MnO 2 was widely used because of its big tunnel structure and MnO 6 octahedral unit, [111] but the low conductivity of MnO 2 (10 À 5 to 10 À 6 S/cm) hindered its use. Baruah et al [112] obtained PEDOT: PSS/MnO 2 /rGO, and it had a better current density was 56.38 mA/cm 2 and initial potential was low (0.32 V) for MOR.…”

Section: Other Transition Metal Catalystsmentioning

confidence: 99%

“…In addition to the widespread use of metals such as Pt, Ni, other transition metals and these transition metal oxides also had potential as catalysts for MOR. Among them, MnO 2 had attracted much focus because of its low cost, good for easy synthesis, and so on [110] . Among some kinds of MnO 2 , particularly, polymorphs, α‐MnO 2 was widely used because of its big tunnel structure and MnO 6 octahedral unit, [111] but the low conductivity of MnO 2 (10 −5 to 10 −6 S/cm) hindered its use.…”

Section: Classification Of Catalystsmentioning

confidence: 99%

Research Progress on Catalysts for the Electrocatalytic Oxidation of Methanol

Ding

Dong

Tang³

2020

ChemistrySelect

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The methanol oxidation reaction has high energy density and the product is non-toxic and harmless (CO 2 , H 2 O), making it become one of the targets of new fuel energy. To maximize the efficiency of the reaction, its key lies in the development of highly efficient catalysts. In this paper, we reviewed the types of methanol electrocatalytic oxidation catalysts in recent years, some new preparation methods, and the reaction mechanism of different types of catalyst systems, and discussed their structure-activity relationships, laying the foundation for the development of highly efficient new catalysts in the future. And this paper is included on the types of catalysts (Pt-based catalyst, Ni-based catalyst, and other transition metal-based catalyst) and preparation methods (Reduction method, sol-gel method, in-situ method), and discussed the catalytic mechanism which mainly starts from two aspects, one is adsorptiondesorption, the other is the bond between the catalyst, methanol, and the medium. Finally, the future challenges and opportunities of the electrocatalytic oxidation of methanol are discussed.

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“…More studies have reported the use of rGO as a template for synthesizing nanocomposite nanomaterials for glucose biosensor fabrication; for example, a NiCo2O4/nitrogen-doped rGO [126], copper sulfide nanoflake-rGO [127], Cu2O/rGO [128], Cux@Ni100-x core-shell NPs-rGO [129], Ni NPs-rGO [130], 3D rambutan-like CuO and CuO/rGO [131], Au NPdecorated GO [132], NiO NPs-MW-CNTs-rGO [133], MnO2/graphene [134], and polydopamine/ZIF-8@rGO [135]. Although they exhibit improved performances, control over the size of nanomaterials and uniformity in supporting rGO remain challenging.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Deposition of nanomaterials: A crucial step in biosensor fabrication

Ahmad

Wolfbeis

Hahn

et al. 2018

Materials Today Communications

178

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 An easy, stable, and reproducible nanomaterial deposition/growth method is crucial for the realization of fabricated biosensor devices' performance, such as device stability, and reproducibility, as well as other sensing properties.  Key challenges for optimum deposition include stability, reproducibility, repeatability, and the ability of deposited nanomaterials to address these challenges is critiqued.

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An amperometric glucose biosensor based on a MnO₂/graphene composite modified electrode

Cited by 48 publications

References 59 publications

Functionalization of CVD Grown Graphene with Downstream Oxygen Plasma Treatment for Glucose Sensors

Functionalization of CVD Grown Graphene with Downstream Oxygen Plasma Treatment for Glucose Sensors

Research Progress on Catalysts for the Electrocatalytic Oxidation of Methanol

Deposition of nanomaterials: A crucial step in biosensor fabrication

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An amperometric glucose biosensor based on a MnO2/graphene composite modified electrode

Cited by 48 publications

References 59 publications

Functionalization of CVD Grown Graphene with Downstream Oxygen Plasma Treatment for Glucose Sensors

Functionalization of CVD Grown Graphene with Downstream Oxygen Plasma Treatment for Glucose Sensors

Research Progress on Catalysts for the Electrocatalytic Oxidation of Methanol

Deposition of nanomaterials: A crucial step in biosensor fabrication

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An amperometric glucose biosensor based on a MnO₂/graphene composite modified electrode