An amperometric sensor based on hemin adsorbed on silica gel modified with titanium oxide for electrocatalytic reduction and quantification of artemisinin

Reys, José Rui M.; Lima, Phabyanno Rodrigues; Cioletti, Alessandra G.; Ribeiro, Adriana S.; Abreu, Fabiane Caxico de; Goulart, Marília Oliveira Fonseca; Kubota, Lauro T.

doi:10.1016/j.talanta.2008.07.043

Cited by 21 publications

(11 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Reys et al developed a feasible alternative method that uses an amperometric detector based on hemin adsorbed on silica gel modified for quantification of artemisinin [ 146 ].…”

Section: Methods Of Analysis Of Sesquiterpene Lactonesmentioning

confidence: 99%

Sesquiterpene Lactones fromArtemisiaGenus: Biological Activities and Methods of Analysis

Ivănescu

Miron

Corciovă

2015

Journal of Analytical Methods in Chemistry

155

118

View full text Add to dashboard Cite

Sesquiterpene lactones are a large group of natural compounds, found primarily in plants of Asteraceae family, with over 5000 structures reported to date. Within this family, genus Artemisia is very well represented, having approximately 500 species characterized by the presence of eudesmanolides and guaianolides, especially highly oxygenated ones, and rarely of germacranolides. Sesquiterpene lactones exhibit a wide range of biological activities, such as antitumor, anti-inflammatory, analgesic, antiulcer, antibacterial, antifungal, antiviral, antiparasitic, and insect deterrent. Many of the biological activities are attributed to the α-methylene-γ-lactone group in their molecule which reacts through a Michael-addition with free sulfhydryl or amino groups in proteins and alkylates them. Due to the fact that most sesquiterpene lactones are thermolabile, less volatile compounds, they present no specific chromophores in the molecule and are sensitive to acidic and basic mediums, and their identification and quantification represent a difficult task for the analyst. Another problematic aspect is represented by the complexity of vegetal samples, which may contain compounds that can interfere with the analysis. Therefore, this paper proposes an overview of the methods used for the identification and quantification of sesquiterpene lactones found in Artemisia genus, as well as the optimal conditions for their extraction and separation.

show abstract

“…Reys et al developed a feasible alternative method that uses an amperometric detector based on hemin adsorbed on silica gel modified for quantification of artemisinin [ 146 ].…”

Section: Methods Of Analysis Of Sesquiterpene Lactonesmentioning

confidence: 99%

Sesquiterpene Lactones fromArtemisiaGenus: Biological Activities and Methods of Analysis

Ivănescu

Miron

Corciovă

2015

Journal of Analytical Methods in Chemistry

155

118

View full text Add to dashboard Cite

show abstract

“…Hemin (iron protoporphyrin IX), the electroactive center of many heme‐proteins, containing iron, with a chloride ligand, has been used to study the redox activity of heme‐proteins and to develop catalytically‐active electrodes for the detection of various species such as NO , NO 2 − , H 2 O 2 [20, 26–28], dissolved oxygen , artemisinin and neurotransmitters . It has a peroxidase‐like activity similar to the enzyme .…”

Section: Introductionmentioning

confidence: 99%

Hemin Modified SnO₂ Films on ITO‐PET with Enhanced Activity for Electrochemical Sensing

et al. 2018

View full text Add to dashboard Cite

We present a simple and efficient method for the preparation of hemin‐modified SnO2 films on low cost, flexible, conducting ITO‐PET substrates to enable the development of a sensitive electrochemical sensor for the determination of H2O2. Using a hydrothermal processing method meant that the SnO2 films can be prepared at low temperatures, compatible with the PET substrate. The properties of the electrodes enable a high hemin loading to be achieved in a stable and functional way, allowing the direct reduction and oxidation of the immobilized hemin and maintaining its high electrocatalytic activity in the reduction of H2O2 on the surface. The results showed a sensitive response linearly proportional to the concentration of H2O2 in the range 1.5 to 90 μM.

show abstract

“…There are several applications for silica gel and it becomes more diversified when it is functionalized with organic and inorganic groups, for different purposes such as: stationary phase in gas chromatography , sensors , adsorption , ion exchange , pre‐concentration of metal ions , catalysis , among others.…”

Section: Introductionmentioning

confidence: 99%

Silica Gel Functionalized with 4‐Amino‐5‐(4pyridyl)‐4H‐1,2,4‐triazole‐3‐thiol and their Use as a Copper Sorbent and Electromediator for Voltammetric Detection of Ascorbic Acid

et al. 2018

View full text Add to dashboard Cite

In this work, the 3‐chloropropyl silica gel (SG) was prepared and organofunctionalized with 4‐amino‐5‐(4pyridyl)‐4H‐1,2,4‐triazole‐3‐thiol (SGA), that was characterized by infrared spectroscopy (FTIR) and cyclic voltammetry (CV). The cupric ions (Cu2+) sorption on the silica functionalized surface (CuSGA) were performed in aqueous solution, at room temperature. It was performed a systematic study about voltammetric behavior of CuSGA, where the cyclic voltammogram of graphite paste electrode modified with CuSGA exhibited a single redox pair with formal potential (Eθ′)=0.30 V assigned to the process Cu+/Cu2+, (KCl 1.0 mol L−1, v=20 mV s−1). The graphite paste electrode modified with CuSGA was sensitive to different concentrations of ascorbic acid and then an analytical curve could be constructed, with a linear response of 6.0×10−6 to 9.0×10−5 mol L−1 (R=0.9988) and a relative standard deviation of ±2.5 % (n=3). The detection limit (3σ) and amperometric sensitivity were 4.78×10−6 mol L−1 and 115.96 mA/mol L−1, respectively.

show abstract

An amperometric sensor based on hemin adsorbed on silica gel modified with titanium oxide for electrocatalytic reduction and quantification of artemisinin

Cited by 21 publications

References 24 publications

Sesquiterpene Lactones fromArtemisiaGenus: Biological Activities and Methods of Analysis

Sesquiterpene Lactones fromArtemisiaGenus: Biological Activities and Methods of Analysis

Hemin Modified SnO₂ Films on ITO‐PET with Enhanced Activity for Electrochemical Sensing

Silica Gel Functionalized with 4‐Amino‐5‐(4pyridyl)‐4H‐1,2,4‐triazole‐3‐thiol and their Use as a Copper Sorbent and Electromediator for Voltammetric Detection of Ascorbic Acid

Contact Info

Product

Resources

About

An amperometric sensor based on hemin adsorbed on silica gel modified with titanium oxide for electrocatalytic reduction and quantification of artemisinin

Cited by 21 publications

References 24 publications

Sesquiterpene Lactones fromArtemisiaGenus: Biological Activities and Methods of Analysis

Sesquiterpene Lactones fromArtemisiaGenus: Biological Activities and Methods of Analysis

Hemin Modified SnO2 Films on ITO‐PET with Enhanced Activity for Electrochemical Sensing

Silica Gel Functionalized with 4‐Amino‐5‐(4pyridyl)‐4H‐1,2,4‐triazole‐3‐thiol and their Use as a Copper Sorbent and Electromediator for Voltammetric Detection of Ascorbic Acid

Contact Info

Product

Resources

About

Hemin Modified SnO₂ Films on ITO‐PET with Enhanced Activity for Electrochemical Sensing