An amphiphilic water-soluble biphen[3]arene with a tunable lower critical solution temperature behavior

Zhang, Wenjie; Yang, Wenzhi; Chen, Jingyu; Wang, Yuhao; Yan, Miaomiao; Zhou, Jiong

doi:10.1039/d2nj03918d

Cited by 7 publications

(5 citation statements)

References 71 publications

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“…162 Biphen[ n ]arenes, including basic biphen[ n ]arenes, functional biphen[ n ]arenes and cage compounds, have received broad research interest owing to the advantages of large cavities and excellent host–guest properties. 163 In particular, biphen[ n ]arenes can be endowed with customizable cavity sizes, replaceable skeletons and binding sites through a modular synthetic strategy. 164 These characteristics make biphen[ n ]arenes exhibit outstanding performances in adsorptive separation.…”

Section: Biphen[n]arene-based Nacsmentioning

confidence: 99%

Potential of nonporous adaptive crystals for hydrocarbon separation

et al. 2023

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Section: Biphen[n]arene-based Nacsmentioning

confidence: 99%

Potential of nonporous adaptive crystals for hydrocarbon separation

et al. 2023

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“…Compared with free drugs, nanoparticles are more easily internalized by tumor cells, reducing the efflux of drugs [ 81 - 83 ] . These factors work together to eliminate cancer drug resistance [ 84 , 85 ] . Chen et al constructed a cationic β-CD-based nanocarrier that co-delivered PTX and Nur77 gene (an orphan nuclear receptor) to eliminate cancer drug resistance [ 86 ] .…”

Section: Cyclodextrins-based Host-guest Nanosystems For Overcoming Ca...mentioning

confidence: 99%

Supramolecular host-guest nanosystems for overcoming cancer drug resistance

Wu,

Yan,

Liang

et al. 2023

Cancer Drug Resist

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Cancer drug resistance has become one of the main challenges for the failure of chemotherapy, greatly limiting the selection and use of anticancer drugs and dashing the hopes of cancer patients. The emergence of supramolecular host-guest nanosystems has brought the field of supramolecular chemistry into the nanoworld, providing a potential solution to this challenge. Compared with conventional chemotherapeutic platforms, supramolecular host-guest nanosystems can reverse cancer drug resistance by increasing drug uptake, reducing drug efflux, activating drugs, and inhibiting DNA repair. Herein, we summarize the research progress of supramolecular host-guest nanosystems for overcoming cancer drug resistance and discuss the future research direction in this field. It is hoped that this review will provide more positive references for overcoming cancer drug resistance and promoting the development of supramolecular host-guest nanosystems.

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“…Among them, the host-guest interactions have received increasing attention. [37][38][39][40][41] Macrocyclic hosts, such as cyclodextrins, calixarenes, cucurbiturils, and pillararenes, have hydrophobic cavities that selectively bind guest molecules. [42] These macrocycles provide a perfect platform for constructing supramolecular chemotherapy systems via host-guest interactions.…”

Section: Introductionmentioning

confidence: 99%

Recent Progress of Supramolecular Chemotherapy Based on Host–Guest Interactions

et al. 2024

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Chemotherapy is widely recognized as an effective approach for treating cancer due to its ability to eliminate cancer cells using chemotherapeutic drugs. However, traditional chemotherapy suffers from various drawbacks, including limited solubility and stability of drugs, severe side effects, low bioavailability, drug resistance, and challenges in tracking treatment efficacy. These limitations greatly hinder its widespread clinical application. In contrast, supramolecular chemotherapy, which relies host–guest interactions, presents a promising alternative by offering highly efficient and minimally toxic anticancer drug delivery. In this review, we provide an overview of recent advancements in supramolecular chemotherapy based on host–guest interactions. We emphasize the significant role it plays in guiding cancer therapy. Drawing on a wealth of cutting‐edge research, we aim to present a timely and valuable resource for individuals interested in the field of supramolecular chemotherapy or cancer therapy. Furthermore, we aspire to contribute to progression of the field of supramolecular chemotherapy toward clinical application.This article is protected by copyright. All rights reserved

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An amphiphilic water-soluble biphen[3]arene with a tunable lower critical solution temperature behavior

Abstract: Supramolecular macrocycles with lower critical solution temperature (LCST) behavior have received extensive attention. Exploring new macrocyclic receptor to achieve tunable LCST behavior is important for the construction and application of...

Cited by 7 publications

References 71 publications

Potential of nonporous adaptive crystals for hydrocarbon separation

Potential of nonporous adaptive crystals for hydrocarbon separation

Supramolecular host-guest nanosystems for overcoming cancer drug resistance

Recent Progress of Supramolecular Chemotherapy Based on Host–Guest Interactions

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