An analgesic effect of Stachys lavandulifolia in patients with migraine: A double-blind randomised clinical trial study

Ashtiani, Alireza Rezaei; Jadidi, Ali; Hezave, Ali Khanmohamadi; Safarabadi, Mehdi; Pour, Seyed Mohamad Aghae; Ghassami, Keivan; Mohammadbeigi, Abolfazl

doi:10.4103/aihb.aihb_31_18

Cited by 7 publications

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“…Since there was no previous clinical trial that tested the efficacy of SSC in humans, by this pilot design of the clinical trial, the duration of 8 weeks and the optimum dosage of 2.4 g/day SSC were considered safe [18]. Previous human studies showed that regularly drinking the Stachys lavandulifolia tea for a considerable duration has no side effects among patients with polycystic ovary syndrome (three times a day, each time a 5-g Stachy added to 100mL boiling water, for 3 months) [27] or at a study population of patients affected by migraine (three times a day, each time 10 g of plant in 200mL of boiling water, for 2 months) [29]. Moreover, there is no evidence available to document neither SSC nor other kinds of Stachys had toxic effects when administered in a dose range of 2-10 g/kg body weight/day of animal models [16,41].…”

Section: Treatmentsmentioning

confidence: 99%

“…Chen et al [28] reported lowered proinflammatory factors (T helper cell-17 and IL-17A) and enhanced anti-inflammatory biomarkers (IL-10) in chronic obstructive pulmonary patients following interventions using Stachys sieboldii Miq granules. Another randomized clinical trial showed that treatment by Stachys lavandulifolia tea caused analgesic effects in patients suffering from migraines [29]. Although there are sufficient in vitro and animal studies showed anti-inflammatory and antioxidant effects of Stachys, there are a few interventional human studies supporting these potentials out of different types of Stachys [27][28][29]; still, no evidence exists to demonstrate the effects of SSC treatment on inflammatory-related clinical outcomes in human.…”

Section: Introductionmentioning

confidence: 99%

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Stachys schtschegleevii tea, matrix metalloproteinase, and disease severity in female rheumatoid arthritis patients: a randomized controlled clinical trial

et al. 2021

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Background Stachys schtschegleevii (SSC) is a herbal medicine used to treat infections. To date, this is the first study aimed to investigate the effects of SSC tea on disease activity score (DAS), serum inflammatory biomarkers and matrix metalloproteinases (MMP-1 and MMP-3) among women with rheumatoid arthritis (RA). Methods This pilot, triple-blind, randomized controlled clinical trial was conducted among forty-four women (age: 30-65 years) diagnosed with moderately active RA. Subjects were randomly assigned (1:1 ratio) into either SSC group (2.4 g/day SSC + 2.4 g/day black tea, n=22) or placebo (2.4 g/day black tea, n=22) for 8 weeks. Serum high-sensitivity C-reactive protein (hs-CRP), interleukin-1 beta (IL-1β), and MMPs were measured using ELISA. According to the American College of Rheumatology guideline considering hs-CRP, DAS28 was assessed. Results Both study groups had respondent rates above 94.9%. The SSC intervention caused significant reductions in the number and the percent changes of the tender joints (SSC: −74.39% vs. placebo: −57.15%, mean differences= −0.77; P<0.05) and DAS28 [SSC: −32.44% vs. placebo: −22.32%, mean differences= −0.41, P<0.05). Unlike the intervention within SSC group that showed significant reductions in the mean serum levels of hs-CRP, IL-1β, and MMP-3, SSC caused significant MMP-3 reductions (SSC: −20.59% vs. placebo: 1.29%, P<0.05). ConclusionThe SSC intervention showed an appropriate clinical efficacy for female RA patients, accompanying remarkable reductions in the number of tender and swollen joints, DAS28, and serum levels of MMP-3. This can provide additional insights to the interventional studies controlling RA-related pathological and inflammatory outcomes. Trial registrationProspectively registered at the Iranian Registry of Clinical Trials (IRCT), linked to the WHO Registry Network (https:// en. irct. ir/ trial/ 11602, IRCT registration number: IRCT2015032011335N5, Registration date:2015-05-12). Key Points• Stachys schtschegleevii improved clinical outcomes and attenuated disease severity in RA patients.• Stachys schtschegleevii ameliorated serum level of

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Section: Treatmentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Stachys schtschegleevii tea, matrix metalloproteinase, and disease severity in female rheumatoid arthritis patients: a randomized controlled clinical trial

et al. 2021

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“…Most researchers believe that the side effects of herbal medicines are less than those of chemical medicines. 18 In this regard, extensive research has been conducted on the use of natural essences. Not only do these essences have antimicrobial properties, but also they have anti-parasite and antitoxic properties, which are related to the types of active ingredients in them.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Antimicrobial Effect of Zataria Multiflora Essence and Deconex Surface on Microbial Load of Emergency Ambulances

Jadidi

Irannejad

Mohsenifard

et al. 2022

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This study aimed to compare the antimicrobial effect of Deconex Surface, a common disinfectant, and Zataria multiflora essence on microbial load of Emergency ambulance equipment in Iran. The samples were selected from all the ambulances through convenience sampling. Before the intervention, the cultures were obtained from the contact surfaces and the surfaces were then disinfected with Deconex and Zataria multiflora. Then, repeated cultures were obtained from the same surfaces. Next, the samples were immediately sent to a microbiology lab. The obtained data were entered into SPSS 2016 and analyzed using statistical tests. Results showed that disinfecting effect of Zataria multiflora is better than Deconex in eliminating certain bacterial species such as Staphylococcus and Bacillus. So Zataria multiflora essence can be used as a surface and hospital equipment disinfectant along with other disinfectant compounds.

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“…It presents with unilateral headache, nausea, vomiting, and sensitivity to light and sound. Half of the attacks are triggered by physiologic or psychological stressors [1, 2]. When untreated or unsuccessfully treated, these attacks usually last 4–72 h [3].…”

Section: Introductionmentioning

confidence: 99%

The Efficacy of Topical Basil Essential Oil on Relieving Migraine Headaches: A Randomized Triple-Blind Study

et al. 2020

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Objective: Complementary therapies have been increasingly used for the prevention and treatment of migraine so that there is a need for studies in this setting. This study sought to determine the effects of basil essential oil on the severity and frequency of migraine attack headaches. Methods: A triple-blind clinical trial study was performed on 144 patients diagnosed with migraine. Patients were randomly allocated by a stratified method to four groups of 36 titled basil essential oil 2, 4, 6%, and placebo groups. Medications were used topically every 8 h for 3 successive months. In addition, each individual received 325 mg of acetaminophen every 12 h. The severity and frequency of migraine attacks were measured prior to the study, at weeks 2, 4, 8, and 12. The visual analog scale was used to measure pain intensity. The marginal model and generalized estimation equations were used to compare changes in the intensity and frequency of pain over time. Results: The interaction of the dose and time factors was significant on both pain intensity (p < 0.001) and frequency of attack (p < 0.001). The odds ratio of higher pain intensity and rate ratio of higher frequency of attack in the intervention groups compared to the placebo group were decreased over the study time. Conclusion: Time lapse and higher doses of basil essential oil would reduce both the intensity and frequency of migraine attacks.

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An analgesic effect of Stachys lavandulifolia in patients with migraine: A double-blind randomised clinical trial study

Cited by 7 publications

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Stachys schtschegleevii tea, matrix metalloproteinase, and disease severity in female rheumatoid arthritis patients: a randomized controlled clinical trial

Stachys schtschegleevii tea, matrix metalloproteinase, and disease severity in female rheumatoid arthritis patients: a randomized controlled clinical trial

Comparison of the Antimicrobial Effect of Zataria Multiflora Essence and Deconex Surface on Microbial Load of Emergency Ambulances

The Efficacy of Topical Basil Essential Oil on Relieving Migraine Headaches: A Randomized Triple-Blind Study

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