An analysis driven construction of distortional-mode-dependent and Hill-Stable elastic potential with application to human brain tissue

Prasad, Durga; Kannan, K.

doi:10.1016/j.jmps.2019.103752

Cited by 6 publications

(2 citation statements)

References 32 publications

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“…Constitutive models should be chosen in relation to the type of experiment and application considered, which in this case are indentation and head impact, respectively. Several models have been employed to characterize the hyperelastic response of the human brain, such as those of Gent (Budday, Sommer, Birkl, et al, 2017), Demiray (Budday, Sommer, Birkl, et al, 2017), Mooney-Rivlin (Budday, Sommer, Birkl, et al, 2017), Ogden (Budday, Sommer, Birkl, et al, 2017;Franceschini et al, 2006;Hosseini-Farid, Ramzanpour, Ziejewski, & Karami, 2019;Moran, Smith, & García, 2014;Prange & Margulies, 2002a), Mihai-Ogden (Mihai, Budday, Holzapfel, Kuhl, & Goriely, 2017) and Prasad-Kannan (Prasad & Kannan, 2020). (MacManus et al, 2018) showed that for microindentation tests with large strain and high strain rate (as in this study), the neo-Hookean model fits the experimental data as well as the Ogden or Mooney-Rivlin models, with the considerable advantage of having only a single material parameter to optimize (instead of at least two) (Pierrat et al, 2018).…”

Section: Suitability Of the Constitutive Lawmentioning

confidence: 99%

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Regional characterization of the dynamic mechanical properties of human brain tissue by microindentation

Menichetti

MacManus

Gilchrist

et al. 2020

International Journal of Engineering Science

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Traumatic brain injury (TBI) is an important cause of mortality and morbidity worldwide. Finite element models of the human head are used widely to simulate TBI loading scenarios, to improve the understanding of the mechanical pathogenesis of head trauma. The reliability of such computational models depends strongly on the accuracy of the mechanical properties of the different components of the brain. Here, we address the shortage of high-quality data on the region-specific properties of human brain tissue at dynamic rates and under large deformation. We mechanically characterized 12 different regions of the human brain including cerebrum, cerebellum and brainstem through n=595 force-relaxation experiments with a custom-built micro-indentation apparatus. We imposed up to 35% strain at 10/s strain rate, i.e. values representative for TBI. Pronounced differences in mechanical response were observed across the brain. This work both highlights and addresses the need to assign accurate, region-specific viscoelastic properties to different brain regions in finite element head models.

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Section: Suitability Of the Constitutive Lawmentioning

confidence: 99%

“…More refined and complex material model definitions, e.g. (Mihai et al, 2017;Prabhu et al, 2011;Prasad & Kannan, 2020), could be used to fit the experimental force-time data collected here, available in the Supplementary material, with the aim to obtain a more realistic representation of the local stress field.…”

Section: Limitations and Future Directionsmentioning

confidence: 99%