An analysis of 10218 ulcerative colitis cases in China

Abstract

In China, number of UC patients increased significantly in the past 10 years. Lesions are commonly located to left side colon. The course is short with rare extraintestinal manifestations. The age of onset is relatively high. Males and females are nearly equally affected. No negative relation was found between smoking and severity of the disease. Familial relatives are rarely involved Traditional Chinese medicine(TCM) is widely used in the treatment of UC.

Different therapy for different types of ulcerative colitis in China

“…According to our statistics, the first episode type accounted for 34.8% of all ulcerative colitis cases in China [3] . The disease mostly starts in rectum and sigmoid colon.…”

“…Therefore, we should place emphasis in the study of UC on more effective drugs with less adverse reactions [2,[27][28][29][30][31] . At present, the cause and pathogenesis of UC are unclear [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] , nonspecific anti-inflammatory drugs, in a relatively long period, will still remain as the main drugs for treating UC. While the curative effect of traditional aminosalicylic acid has been affirmed, its side reactions are too many.…”

“…Imodium may also be given temporarily to some patients to maintain curative effect. In China, the chronic relapse type accounted for 52.6% of all UC cases [3] , maintenance treatment may lower relapse rate. In summary, this study shows that the curative effect and safty of domestic olsalazine sodium is superior to SASP in the treatment of chronic UC.…”

“…Two patients relapsed in olsalazine sodium group while 8 cases relapsed in SASP group during the flow-up period (from six months to one year). In the 42 first episode type UC patients, the clinical effect of Heartleaf houttuynia herb group (complete remission in 20, 95.2%; improvement in 1, 4.8%) was better than that of SASP group (complete remission in 15 3.7±1.7 cm/min, P<0.05). In normal persons, the postprandial pressure of sigmoid (2.9 ±0.9 kPa) was higher than that of descending colon (2.0±0.7 kPa) and splenic flexure (1.7±0.6 kPa), while the colonic pressure (1.5±0.5 kPa, 1.4±0.6 kPa, 1.3±0.6 kPa) decreased significantly (P<0.05) in active UC patients.…”

“…But recent reports reveal that UC cases have increased remarkably [1,2 ] . According to our study, UC cases from 1991 to 2000 have increased 2.7 times compared with those from 1981 to 1990 [3][4][5] . Due to the fact that the etiology and mechanism of UC are still not quite clear, and there is no specific treatment available, the disease usually becomes chronic with repeated relapses, thus seriously endangering patient's health [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] .…”