African American women are continually engaged in challenging invisibility, marginalization, and exclusion. Africana Sociology has the potential to support these efforts by incorporating key conceptual models and constructs from Black Sociology, Afrocentricity, and Transdisciplinary Applied Social Justice (TASJ©). Africana Sociology should recognize the role of intersectionality and socially-constructed and intertwined race, class, and gender identities; it should acknowledge the importance of African-centered thought, including the role of Ma’at; and it should reflect a commitment to praxis – using theory to transform social institutions and thus, social outcomes. With this conceptual foundation, Africana Sociology can serve as a theoretical, methodological, and practical approach for implementing transformative change in the experiences of African Americans, and African American women, in particular.