Spatial heterogeneity in predation risk can ameliorate impacts on prey 27 populations, particularly for prey of generalists. Spatially heterogeneous risk implies the 28 existence of refugia, and the spatial scale of those refugia and their persistence over time affect 29 whether prey can avoid predation by aggregating therein. Our objective was to quantify the 30 magnitude, spatial scale, and temporal persistence of heterogeneity in risk of predation by 31 white-footed mice (Peromyscus leucopus), an abundant generalist predator of gypsy moths 32 (Lymantria dispar) and songbirds. We used track plates to measure white-footed mouse activity 33 at >170 trees in each of 3 forest plots in upstate New York during summers of [2003][2004][2005]. We 34 quantified the mean and coefficient of variation of track activity among trees by fitting the 35 beta-binomial distribution to data from each plot and study period. We measured temporal 36 persistence by disattenuated autocorrelation, and spatial scale by fitting exponential variograms. These findings indicate that mouse activity, and hence risk to their prey, varies substantially in 43 space at spatial and temporal scales that appear responsive to mouse population dynamics. The 44 spatial scale and temporal persistence of that variation imply that prey may benefit from 45 returning to, or failing to disperse from, refugia. 46