An analysis of clinical characteristics and postoperative complications in children craniopharyngioma

Deng, Yaxian; Yao, Chen; Xu, Jin; Wang, Lei; Gong, Jian; Zhao, Chunli

doi:10.1007/s00381-021-05277-7

Cited by 9 publications

(17 citation statements)

References 26 publications

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“…ACP is a rare disease that seriously impacts human health 17 . The prognosis of ACP patients after radiotherapy and surgical resection is poor 18 . Therefore, it is urgent that we seek new treatment methods.…”

Section: Discussionmentioning

confidence: 99%

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Analysis of KLRB1-Mediated Immunosuppressive Regulation in Adamantinomatous Craniopharyngioma

Wei,

Hong

2024

J Neurol Surg A Cent Eur Neurosurg

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Background: Adamantinomatous craniopharyngioma (ACP) is the most common type of craniopharyngioma (CP). Under the current surgery and/or radiotherapy strategies, the survival rate is high but the long-term quality of life is poor because of the relationship between the hypothalamic-pituitary and the tumor. Many studies had shown that endocrine deficiencies caused by craniopharyngiomas of the hypothalamic-pituitary axis persist throughout almost the entire life of the patients after surgery, requiring them to receive hormone replacement therapy. Thus, we need to explore new treatments to improve the prognosis of patients. In recent years, there are more and more studies on immunotherapy of various tumors. However, due to the rarity of the disease, immunotherapy for ACP is rarely researched. The discovery of the tumor immunosuppressive checkpoint KLRB1 (Killer Cell Lectin Like Receptor B1), which encodes CD161, may provide a novel target for the treatment of ACP. Methods: Data analysis of retrospective RNA-sequencing was conducted in a cohort of 51 pediatric samples in the GSE94349 dataset, and the results were well validated in the GSE68015 dataset including 31 pediatric samples. We used R language as the main tool for statistical analysis and graphical work. Results: Our research showed that KLRB1 was enriched in ACP. Additionally, the expression of KLRB1 was positively related to immune functions and most inflammatory responses of ACP. We found that most of the T lineage–related immune responses were positively correlated with KLRB1 expression, and KLRB1 played an important role in the activation of inflammatory processes. Conclusions: KLRB1 is a promising target for immunotherapeutic strategies.

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Section: Discussionmentioning

confidence: 99%

“…17 The prognosis of ACP patients after radiotherapy and surgical resection is poor. 18 Therefore, it is important that we find new treatment methods urgently. The success of immunotherapy in various tumor types has been demonstrated; however, no targeted immunotherapies have been developed for ACP.…”

Section: Discussionmentioning

confidence: 99%

Analysis of KLRB1-Mediated Immunosuppressive Regulation in Adamantinomatous Craniopharyngioma

Wei,

Hong

2024

J Neurol Surg A Cent Eur Neurosurg

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“…Childhood and adolescence are important stages in the physical development and maturation of secondary sexual characteristics, which require a variety of hormones to play a synergistic role in achieving natural physical development. Normal pituitary hormone replacement is critical to decreasing the morbidity associated with the endocrine and metabolic consequences of CP [37]. Therefore, we must pay more attention to hormone deficiency in children with CP.…”

Section: Discussionmentioning

confidence: 99%

Risk Factor and Replacement Therapy Analysis of Pre- and Postoperative Endocrine Deficiencies for Craniopharyngioma

Cheng

Zhu

Wang

et al. 2023

Cancers

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Background: Pituitary hormone deficiency (PHD) is one of the most common symptoms and postoperative complications of craniopharyngiomas (CPs). However, the risk factors for PHD in CPs are little known. The purpose of this study was to analyze the risk factors of pre- and postoperative PHD and to investigate replacement therapy for CP patients. Methods: A retrospective study of 126 patients diagnosed with CP was performed. Univariate analysis was performed using Pearson’s chi-squared test or Fisher’s exact test, and a multiple logistic binary regression model was used to identify the influencing factors of pre- and postoperative PHD in craniopharyngioma. Results: Children and patients with hypothalamic involvement were more likely to have preoperative PHD. Patients with suprasellar lesions had a high risk of postoperative PHD, and preoperative PHD was a risk factor for postoperative PHD. Conclusion: Children have a high incidence of preoperative PHD. Preoperative PHD can serve as an independent risk factor for postoperative PHD. Preoperative panhypopituitarism can serve as an indication of pituitary stalk sacrifice during surgery. The management of replacement therapy for long-term postoperative endocrine hormone deficiency in patients with craniopharyngioma should be enhanced.

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“…Precocious puberty has already been reported as a very rare manifestation of craniopharyngioma [25][26][27][28][29][30][31]. The majority of patients diagnosed with craniopharyngioma initially present with headaches, vomiting, visual impairment, and stunted growth [32][33][34]. Endocrinological pathologies can also be found in the vast majority of patients at admission, while typically they do not constitute the principal presenting complaints [27,35].…”

Section: Discussionmentioning

confidence: 99%

Surgical Treatment of Pediatric Incidentally Found Brain Tumors: A Single-Center Experience

et al. 2023

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There remains much debate about the correct management of incidentally found brain tumors in the pediatric population. This study aimed to evaluate the efficacy and safety of surgical treatment of incidentally found pediatric brain tumors. A retrospective analysis of pediatric patients who underwent surgical resection of incidentally found brain tumors between January 2010 and April 2016 was performed. A total of seven patients were included. The median age at the time of diagnosis was 9.7 years. The reasons for performing neuroimaging were as follows: impeded speech development (n = 2), shunt control (n = 1), paranasal sinuses control (n = 1), behavior changes (n = 1), head trauma (n = 1), and preterm birth (n = 1). Five patients underwent gross total tumor resection (71.4%), while subtotal resection was performed in two patients (28.6%). There was no surgery-related morbidity. Patients were followed up for a mean of 79 months. One patient with atypical neurocytoma experienced tumor recurrence 45 months following primary resection. All patients remained neurologically intact. The majority of pediatric incidentally found brain tumors were histologically benign. Surgery remains a safe therapeutic approach associated with favorable long-term outcomes. Considering the expected long lifetime of pediatric patients, as well as the psychological burden associated with having a brain tumor as a child, surgical resection can be considered an initial approach.

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An analysis of clinical characteristics and postoperative complications in children craniopharyngioma

Cited by 9 publications

References 26 publications

Analysis of KLRB1-Mediated Immunosuppressive Regulation in Adamantinomatous Craniopharyngioma

Analysis of KLRB1-Mediated Immunosuppressive Regulation in Adamantinomatous Craniopharyngioma

Risk Factor and Replacement Therapy Analysis of Pre- and Postoperative Endocrine Deficiencies for Craniopharyngioma

Surgical Treatment of Pediatric Incidentally Found Brain Tumors: A Single-Center Experience

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