1987
DOI: 10.1152/jappl.1987.63.3.1130
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An analysis of decrements in vital capacity as an index of pulmonary oxygen toxicity

Abstract: Decrements in vital capacity (% delta VC) were proposed by the Pennsylvania group in the early 1970s as an index of O2-induced lung damage. These workers used the combined effects of PO2 and time of exposure to develop recommendations to limit expected % delta VC. Adopting this general approach, we fitted human pulmonary O2 toxicity data to the hyperbolic equation % delta VC = Bs.(PO2 - B1).(time)B3 using a nonlinear least squares analysis. In addition to the data considered in 1970, our analysis included new … Show more

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Cited by 38 publications
(33 citation statements)
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“…1b). The cumulative hyperoxic exposure in excess of 30 and 40 kPa and CPTD were also calculated, since a threshold for PO 2 resulting in lung function changes has been suggested [14,15]. Cumulative hyperbaric exposure was calculated in the same way.…”
Section: Assessment Of Exposurementioning
confidence: 99%
“…1b). The cumulative hyperoxic exposure in excess of 30 and 40 kPa and CPTD were also calculated, since a threshold for PO 2 resulting in lung function changes has been suggested [14,15]. Cumulative hyperbaric exposure was calculated in the same way.…”
Section: Assessment Of Exposurementioning
confidence: 99%
“…Once the amount of UPTD is calculated, this number must be compared with a reference table (table 2), which relates the dose to the predicted percentage of decrease in VC [48,51]. The maximum UPTD for ordinary professional diving is 615, whereas the upper limit for a single exceptional exposure is set at 1425 UPTD [48].…”
Section: Introductionmentioning
confidence: 99%
“…The validity of this assertion is subject to the assumptions that all exposures were independent and that the true DCS risks of all the profiles are equal; both of which are certainly violated in this data. Nevertheless, the 2.7% figure compares favorably with the estimated risks of current U.S. Navy Standard Air Decompression schedules, which vary widely from fractions of one percent to greater than 10% under the probabilistic models available to make such estimates 4,5,6 . Within these schedules, the mean DCS risk of air dives to the no-stop limits is 2.2% and 2.1% under the BVM(3) and USN93 models, respectively 7 .…”
Section: Experimental Profilesmentioning
confidence: 83%
“…The DCS risks predicted by the Duke Gas and Bubble Dynamics model [BVM (3)] 1 ' 2 , the NMRI JAP98 model 2 (JAP98-2) 3 , and the USN93 4,5 model for the tested profiles are listed in Table 1. Evidence indicates that the water temperature has a minimal effect on the occurrence of DCS, although a trend toward higher DCS incidences has been noted in divers wearing hot water suits and performing stressful dives 6 . Warm water may increase the uptake of gas into tissues, and may increase the risk of DCS.…”
Section: Appendix a Issues Considered In Selection Of Test Profilesmentioning
confidence: 99%
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