The nursing faculty must prepare students to meet challenges through the provision of adequate and evidence-based services amid complexities in the healthcare system. This study aims to determine the differences in demographic characteristics of the nursing students that may factor in the application of evidence-based practice. The researcher employed a quantitative comparative approach. There were 213 nursing students from the College of Nursing, the University of Hail, who served as respondents in this study. Simple random sampling was used as the sampling technique. This study used the Student Evidence-based Practice Questionnaire (S-EBPQ) for data-collection. Data were treated with the T-test to determine the difference between sex and the use of the evidence-based practice. The age and year level was tested using a one-way analysis of variance (ANOVA) tests. This study was carried out in December 2019 through February 2, 2020. There was no significant difference between the use of evidence-based practice for males (M=4.61, SD=0.90) while the female (M=4.48, SD=1.03) with t(211)=0.96. Meanwhile, there is a significant difference between age and the use of EBP by one-way ANOVA (F (2,210)=9.48, p=<0.001), and year level and the use of EBP by one-way ANOVA (F (3,209)=155.24, p=<0.001), with a partial effect size of 0.69. Demographic information of the student nurses such as sex is not significant to implementing EBP, but age and year level has been found to be determinants in implementing the EBP. Findings contribute to the development of the improvement of the program curriculum to reinforce the involvement of students in learning and practicing the evidence-based process.