An Analysis of JADE2 in Non-Small Cell Lung Cancer (NSCLC)

Abstract

The JADE family comprises three members encoded by individual genes and roles for these proteins have been identified in chromatin remodeling, cell cycle progression, cell regeneration and the DNA damage response. JADE family members, and in particular JADE2 have not been studied in any great detail in cancer. Using a series of standard biological and bioinformatics approaches we investigated JADE2 expression in surgically resected non-small cell lung cancer (NSCLC) for both mRNA and protein to examine for correlations between JADE2 expression and overall survival. Additional correlations were identified using bioinformatic analyses on multiple online datasets. Our analysis demonstrates that JADE2 expression is significantly altered in NSCLC. High expression of JADE2 is associated with a better 5-year overall survival. Links between JADE2 mRNA expression and a number of mutated genes were identified, and associations between JADE2 expression and tumor mutational burden and immune cell infiltration were explored. Potential new drugs that can target JADE2 were identified. The results of this biomarker-driven study suggest that JADE2 may have potential clinical utility in the diagnosis, prognosis and stratification of patients into various therapeutically targetable options.

Multi-ancestry meta-analyses of lung cancer in the Million Veteran Program reveal novel risk loci and elucidate smoking-independent genetic risk

“…XCL2 , NMUR2, and TULP3 may also be related to cancer progression via G-protein-coupled receptor (GPCR) signaling pathways 57 . JADE2 expression has been experimentally linked to NSCLC 58 , and has been identified in GWAS of smoking behavior 34 . Finally, DNA damage repair mechanisms emerge, including RPAP3 , an RNA polymerase that may be involved in DNA damage repair regulation 59 , and MMS22L which repairs double strand breaks 60 .…”

Deciphering the dual roles of PHD finger proteins from oncogenic drivers to tumor suppressors

“…JADE family members JADE2 and JADE3 are key members involved in chromatin remodeling and cell cycle regulation, surface as a hallmark of cancer progression. Findings on non-small cell lung cancer (NSCLC) reveal that JADE2’s heightened expression correlates with improved 5-year survival rates, underscoring its role in tumorigenesis ( Murphy et al, 2023 ). Actual understanding of the specific proteins that co-function with JADE2 to regulate chromatin structure is currently limited.…”