Education is the most powerful weapon that can be put to use to change the world and requires a good head and a good heart for its effectuality. Higher education is an umbrella encompassing all types of education as provided by universities, technological institutes, teacher training colleges and normally intended for students who have completed secondary education and have an educational objective of acquisition of a title, a grade, certificate, or diploma of higher education. Higher education is facing a myriad of challenges that are impacting negatively towards its progress and performance. To forestall such, transformational leadership has been touted as a game changer that when applied can be beneficial in aiding higher education recourse and adopt a trajectory geared towards its betterment. The chapter highlights key components that transformational leadership impacts to cause necessary changes and realignments: training of leaders, financial management, collaboration partnerships, technology, inclusivity and diversity, and innovation.