An analysis of the dissipation of pharmaceuticals under thirteen different soil conditions

Kodešová, Radka; Kočárek, Martin; Klement, Aleš; Golovko, Oksana; Koba, Olga; Fér, Miroslav; Nikodem, Antonín; Vondráčková, Lenka; Jakšík, Ondřej; Grabic, Roman

doi:10.1016/j.scitotenv.2015.11.085

Cited by 104 publications

(47 citation statements)

References 51 publications

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“…This behavior suggests that microbial activity may have contributed less to the observed dissipation in these sediments and that the observed loss was caused by abiotic processes. The observed half‐lives for atenolol are greater than the DT50s of between 2.8 and 10.3 d observed by Kodešová et al () in soil. They showed that dissipation of the compound is slow in soil with a higher adsorption affinity to atenolol.…”

Section: Resultscontrasting

confidence: 60%

Factors affecting the dissipation of pharmaceuticals in freshwater sediments

Al-Khazrajy

Bergström

Boxall

2017

Enviro Toxic and Chemistry

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Degradation is one of the key processes governing the impact of pharmaceuticals in the aquatic environment. Most studies on the degradation of pharmaceuticals have focused on soil and sludge, with fewer exploring persistence in aquatic sediments. We investigated the dissipation of 6 pharmaceuticals from different therapeutic classes in a range of sediment types. Dissipation of each pharmaceutical was found to follow first‐order exponential decay. Half‐lives in the sediments ranged from 9.5 (atenolol) to 78.8 (amitriptyline) d. Under sterile conditions, the persistence of pharmaceuticals was considerably longer. Stepwise multiple linear regression analysis was performed to explore the relationships between half‐lives of the pharmaceuticals, sediment physicochemical properties, and sorption coefficients for the compounds. Sediment clay, silt, and organic carbon content and microbial activity were the predominant factors related to the degradation rates of diltiazem, cimetidine, and ranitidine. Regression analysis failed to highlight a key property which may be responsible for observed differences in the degradation of the other pharmaceuticals. The present results suggest that the degradation rate of pharmaceuticals in sediments is determined by different factors and processes and does not exclusively depend on a single sediment parameter. Environ Toxicol Chem 2018;37:829–838. © 2017 SETAC

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Section: Resultscontrasting

confidence: 60%

Factors affecting the dissipation of pharmaceuticals in freshwater sediments

Al-Khazrajy

Bergström

Boxall

2017

Enviro Toxic and Chemistry

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“…Three compounds (Table 2) were selected from a set of seven pharmaceuticals that have been applied previously by Kodešová et al (2015Kodešová et al ( , 2016 or by Kočárek et al (2016) in an evaluation of the impacts of soil properties on sorption affinities, or in an assessment of dissipation half-lives in various soils taken from 11 topsoils and 2 substrates. Pharmaceuticals (Table 2) were chosen based on their different forms depending on pH (Table 1) of the soil-water environment, their pKa values (Table 2) and their corresponding sorption behaviour (Kodešová et al 2015): atenolol (cation), sulfamethoxazole (anion) and carbamazepine (neutral).…”

Section: Methodsmentioning

confidence: 99%

Sorption of atenolol, sulfamethoxazole and carbamazepine onto soil aggregates from the illuvial horizon of the Haplic Luvisol on loess

Fér¹,

Kodešová²,

Golovko³

et al. 2018

Soil Water Res.

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Fér M., Kodešová R., Golovko O., Schmidtová Z., Klement A., Nikodem A., Kočárek M., Grabic R. (2018): Sorption of atenolol, sulfamethoxazole and carbamazepine onto soil aggregates from the illuvial horizon of the Haplic Luvisol on loess. Soil & Water Res., 13: 177−183.The leakage of pharmaceuticals present in soils towards groundwater is largely controlled by sorption of those compounds in soils. In some soils, soil aggregates are covered by coatings, which may have considerably different composition in comparison to that in an inner part of the aggregates. The aim of this study was to evaluate the sorption of three pharmaceuticals, which were applied in single or all compounds solutions, onto soil samples taken from the Bt horizon of a Haplic Luvisol. Analyses were performed on three types of disturbed soil samples: (1) entire aggregates, (2) aggregates from which coatings were removed, and (3) clay-organic coatings. Sorption of atenolol onto material from coatings was slightly higher than that onto material from the inner parts of the aggregates. On the other hand, sorption of sulfamethoxazole onto material from the coatings was lower than that from the aggregate interior. Both associates with a dominant fraction of clay particles (that are mostly negatively charged) in the coatings in comparison to soil composition in interiors and thus larger cation exchange capacity, which increased sorption of the positively charged atenolol and decreased sorption of the negatively charged sulfamethoxazole. Sorption of carbamazepine, which was in neutral form, did not substantially differ. The sorption of all three compounds did not decrease due to the competition between these compounds for the same sorption sites when applied simultaneously. Atenolol sorption was similar for both applications. Sorption of sulfamethoxazole increased when applied in solution with the other two compounds in comparison to its negligible sorption measured for the single compound solution likely due to sorption of the positively charged molecules of atenolol onto the negatively charged surface of soil components and reduction of repulsion between the soil components and the negatively charged molecules of sulfamethoxazole. Carbamazepine sorption also increased probably due to ionization of molecules due to dipole -induced dipole interaction between non-polar and polar molecules in solution.

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“…The low concentrations of the CAR metabolites (Figures 2a and 2b) indicated that CAR was not considerably transformed in the soils by microbial activity or other chemical processes taking place in a soil environment (Koba et al, 2016;Kodešová et al, 2016). On the other hand, CAR was greatly metabolized in plant bodies (Figures 2c and 2d).…”

Section: Bioaccumulation Of Pharmaceuticals and Their Metabolites -Nementioning

confidence: 99%

Uptake, translocation and transformation of three pharmaceuticals in green pea plants

Klement

Kodešová

Golovko

et al. 2020

Journal of Hydrology and Hydromechanics

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Treated water from wastewater treatment plants that is increasingly used for irrigation may contain pharmaceuticals and, thus, contaminate soils. Therefore, this study focused on the impact of soil conditions on the root uptake of selected pharmaceuticals and their transformation in a chosen soil–plant system. Green pea plants were planted in 3 soils. Plants were initially irrigated with tap water. Next, they were irrigated for 20 days with a solution of either atenolol (ATE), sulfamethoxazole (SUL), carbamazepine (CAR), or all of these three compounds. The concentrations of pharmaceuticals and their metabolites [atenolol acid (AAC), N1-acetyl sulfamethoxazole (N1AS), N4-acetyl sulfamethoxazole (N4AS), carbamazepine 10,11-epoxide (EPC), 10,11-dihydrocarbamazepine (DHC), trans-10,11-dihydro-10,11-dihydroxy carbamazepine (RTC), and oxcarbazepine (OXC)] in soils and plant tissues were evaluated after harvest. The study confirmed high (CAR), moderate (ATE, AAC, SUL), and minor (N4AC) root uptake of the studied compounds by the green pea plants, nonrestricted transfer of the CAR species into the different plant tissues, and a very high efficiency in metabolizing CAR in the stems and leaves. The results showed neither a synergic nor competitive influence of the application of all compounds in the solution on their uptake by plants. The statistical analysis proved the negative relationships between the CAR sorption coefficients and the concentrations of CAR, EPC, and OXC in the roots (R = –0.916, –0.932, and –0.925, respectively) and stems (R = –0.837, –0.844, and –0.847, respectively).

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An analysis of the dissipation of pharmaceuticals under thirteen different soil conditions

Cited by 104 publications

References 51 publications

Factors affecting the dissipation of pharmaceuticals in freshwater sediments

Factors affecting the dissipation of pharmaceuticals in freshwater sediments

Sorption of atenolol, sulfamethoxazole and carbamazepine onto soil aggregates from the illuvial horizon of the Haplic Luvisol on loess

Uptake, translocation and transformation of three pharmaceuticals in green pea plants

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