An analysis of the effect of ischaemia on testicular ultrastructure

Kaya, Mehmet; Harrison, R. G.

doi:10.1002/path.1711170209

Cited by 55 publications

(22 citation statements)

References 27 publications

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“…3 Ultrastructural damage has been described as early as 1-3 h following ischemia. 4 Ischemia is a decrease in blood flow to organs and it results in elevated levels of lactic acid and hypoxanthine as a result of ATP breakdown and lipid peroxides. During the reperfusion process, with the resumption of blood flow, xanthine oxidase converts hypoxanthine to uric acid and produces large quantities of superoxide radicals which are responsible for reperfusion injury.…”

Section: Introductionmentioning

confidence: 99%

Protective effects of trapidil in ischemia–reperfusion injury due to testicular torsion and detorsion: An experimental study

Somuncu¹,

Çakmak²,

Erdoğan³

et al. 2006

Int J of Urology

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Objective: We aimed to detect the preventive effects of trapidil in ischemia-reperfusion (IR) injury due to testicular torsion and detorsion. Methods: Forty prepubertal albino rats were used. In the IR group, torsion was created by rotating the left testis over 2 h, and detorsion was done by untwisting the testis. Bilateral orchiectomies were performed after 4 h. In study group, 2-h torsion was performed and trapidil was administered as a single dose 1 h before detorsion. Bilateral orchiectomies were performed after 4 h. In the sham group, a sham operation was done. In the sham plus trapidil group, a sham operation was done and trapidil was administered as a single dose. Testicular tissue malondialdehyde (MDA), nitric oxide (NO) and total sulfhydryl (T-SH) levels were determined for each group. The grades of interstitial injury were determined in histopathologic examination. Results: The NO and MDA levels in the IR group were significantly higher than the study, sham and sham plus trapidil groups in the left testis (P < 0.05, P < 0.001 and P < 0.001, respectively). A statistical difference was not found among study, sham and sham plus trapidil groups in the left testis in NO and MDA levels (P > 0.05). The T-SH level in the study group was significantly higher than in the IR, sham and sham plus trapidil groups in left testis P < 0.05). In the IR group (left testis), grade 1 interstitial injury was 30% (3/10), grade 2 injury was 60% (6/10) and grade 3 injury was 10% (1/10). In the study group (left testis), grade 1 interstitial injury was 30% (3/10) and there was no injury in 70% (7/10). Conclusion: Trapidil decreased free oxygen radical formation in testicular torsion and detorsion, and attenuated histopathological damage in the ipsilateral twisted testis.

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Section: Introductionmentioning

confidence: 99%

Protective effects of trapidil in ischemia–reperfusion injury due to testicular torsion and detorsion: An experimental study

Somuncu¹,

Çakmak²,

Erdoğan³

et al. 2006

Int J of Urology

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“…Testicular injury caused by high ligation of the spercollapsed arterioles in the contralateral testis during UTT. The diameters of the uncollapsed arterioles in the matic vessel does not aÂect the contralateral testis [29], while testicular injury created by ligation of the testicular contralateral testis during UTT were not less than in controls, suggesting that all arterioles in the testis do artery at the lower pole of the testis results in contralateral testicular deterioration [30]. Furthermore, contralatnot undergo vasospasm uniformly, but some collapse totally while others maintain their diameter.…”

Section: Discussionmentioning

confidence: 99%

Histological evidence of decreased contralateral testicular blood flow during ipsilateral testicular torsion

Ciftci¹,

Müftüoğlu

Çakar

et al. 1997

British Journal of Urology

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Objective To evaluate contralateral testicular blood flow eral testes of the torsion group were collapsed. The diÂerence between the contralateral testes of the two by histological examination of arterioles during ipsilateral testicular torsion.groups and between the ipsilateral and contralateral testes in the torsion group were significant. The diamMaterials and methods The study comprised two groups of 20 male albino rats (weight 250-270 g). The eter of uncollapsed arterioles did not diÂer significantly among either testes of the control and torsion groups control group underwent a sham operation, while in the second group the left testes were twisted clockwise and either testes in each group. Both testes in the torsion group had significantly more arterioles conby 720°. All rats underwent bilateral orchidectomy 24 h after the initial intervention. Three slides for taining blood cells than those in the control group. The diÂerence between the testes in the torsion group each testis (n=240) were evaluated randomly while unaware of treatment to determine the total number was also significant, but was not in the control group. Conclusion There was histological evidence of decreased of arterioles, the percentage of collapsed and open arterioles, the diameter of open arterioles and the blood flow in the contralateral testis during unilateral testicular torsion; contralateral testicular damage presence or absence of blood cells in the lumen. DiÂerences were assessed using t-tests for paired and during unilateral testicular torsion may result from hypoxia caused by decreased blood flow. independent samples. Results Very few arterioles were collapsed in both testes Keywords Spermatic cord torsion, testicular injury, contralateral of the control group and in the ipsilateral testes of the torsion group, but half the arterioles in the contralatepisodes of contralateral testicular torsion and underlying

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“…radiation, hyperthermia and ischaemia [Choudhury and Steinberger, 1964;Rao and Shrivastava, 1967;Parvinen, 1973;Kaya and Harrison, 1975], All the above factors damage the germinal epi thelium resulting in the arrest of spermato genesis. The temporary (reversal or cyclic) arrest of spermatogenesis invariably occurs in the seasonally breeding mammals in their annual regression period [Reddy and Prasad, 1968;Millar and Glover, 1970], and the giant cells are observed also in the testes of the hedgehog at the beginning of winter regres sion.…”

Section: Resultsmentioning

confidence: 99%

Phase microscope study of the giant cells from the normal testes of the Indian hedgehog, <i>Paraechinus micropus</i>

Bidwai¹,

Bawa²

1977

Cells Tissues Organs

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The phase-optic study of the germinal cells from the testes of the hedgehog, a seasonally breeding mammal, reveals the multinucleate giant cells in the natural state in late August, at the beginning of winter regression without subjecting these animals to any type of experimental stress. The participation of primary spermatocytes and spermatogonia, in addition to spermatids, in the formation of these giant cells has been observed. The nuclei at similar stage of spermatogenesis are identifiable in a single giant cell. The possible mechanism of their formation is discussed.

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An analysis of the effect of ischaemia on testicular ultrastructure

Cited by 55 publications

References 27 publications

Protective effects of trapidil in ischemia–reperfusion injury due to testicular torsion and detorsion: An experimental study

Protective effects of trapidil in ischemia–reperfusion injury due to testicular torsion and detorsion: An experimental study

Histological evidence of decreased contralateral testicular blood flow during ipsilateral testicular torsion

Phase microscope study of the giant cells from the normal testes of the Indian hedgehog, <i>Paraechinus micropus</i>

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