An analysis of the inhibition of phrenic motoneurones which occurs on stimulation of some cranial nerve afferents

Biscoe, T. J.; Sampson, Sanford R.

doi:10.1113/jphysiol.1970.sp009170

Cited by 56 publications

(25 citation statements)

References 16 publications

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“…25-30 msec), an accompaying rebound excitation and a period of the reduced extent of the second inhibition lasting 20-30 msec after the first one. A similar phrenic inhibition due to disfacilitation has been noted by Biscoe and Sampson (1970b). Therefore, it would be mediated by an unidentified group of inhibitory interneurons with a self limiting mechanism.…”

Section: Discussionsupporting

confidence: 68%

Stereotyped phrenic response to laryngeal afferent volleys: The mechanism and anesthetic sensitivity.

Sakai

1988

Tohoku J. Exp. Med.

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04SAKAI, Y. Stereotyped Phrenic Response to Laryngeal A fferent Volleys : The Mechanism and Anesthetic Sensitivity. Tohoku J. Exp. Med., 1988, 156, Suppl., 33-41-The stereotyped reflex changes in phrenic discharge, produced by train(s) of electrical shocks to myelinated afferents in the internal branch of the superior laryngeal nerve (SLN), were studied in vagotomized cats and rabbits, mechanically ventilated with the mixture of oxygen and nitrous oxide. Single weak shocks caused a short latency (4-5 msec) phrenic response, an excitation followed by a slight inhibition for 10 msec, which was repeatable at a rate of 200 Hz or more. Repeated weak shocks at a rate higher than 100 Hz or single stronger shocks caused a powerful inhibition with a limited duration (25-30 cosec) of both the central inspiratory activity (CIA) and short latency response. This stereotyped inhibition, which was followed by a rebound excitation, could occur every 30-50 msec with some reduction and was apparently associated with a decreased slope of integrated phrenicogram. During inhalation of halothane (0.5-1.5%), the short latency phrenic response was reduced, while the stereotyped inhibition and the reduction of phrenic augmentation were markedly enhanced when the CIA was slightly depressed by halothane inhalation. Therefore, the stereotyped inhibition would represent an important mechanism of the reflex slowing of inspiration produced by myelinated laryngeal afferents. myelinated laryngeal afferents ; short latency phrenic response ; stereotyped inhibition ; inspiratory slowing ; susceptibility to halothane

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Section: Discussionsupporting

confidence: 68%

Stereotyped phrenic response to laryngeal afferent volleys: The mechanism and anesthetic sensitivity.

Sakai

1988

Tohoku J. Exp. Med.

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“…This may indicate that these three unrelated afferent inputs impinge on the respiratory effector mechanism at a common point. Biscoe & Sampson (1970) have demon-strated that medullary inspiratory neurones constitute at least part of the neural substrate for superior laryngeal reflexes, and have suggested that the phrenic inhibition involved disfacilitation.…”

Section: Discussionmentioning

confidence: 99%

Extra‐segmental reflexes derived from intercostal afferents: phrenic and laryngeal responses

Remmers¹

1973

The Journal of Physiology

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SUMMARY1. Phrenic and recurrent laryngeal efferent responses were evoked by brief tetani or single shocks to the cut external intercostal nerves of anaesthetized cats. The reflexes derived from middle thoracic segments (T5 and 6) were compared with those emanating from caudal thoracic segments (T9 and 10).2. During inspiration, middle intercostal nerve stimulation transiently inhibited the spontaneous discharge in both efferent neurograms, whereas stimulation of caudal intercostal nerves facilitated phrenic discharge and usually inhibited recurrent laryngeal activity.3. During expiration, stimulation at either thoracic level enhanced recurrent laryngeal discharge while provoking little or no phrenic response.4. Superficial lesions of the lateral cervical cord, ipsilateral to the stimulus sites, above or below the phrenic outflow, eliminated all reflex responses except the phrenic response to caudal thoracic stimuli. Similarly, in the spinal animal, middle intercostal afferents could not be shown to decrease phrenic excitability. Caudal intercostal afferents cause phrenic excitation by a spinal reflex.5. Group

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“…On some occasions Iriuchijima & Kumada were able to evoke vagal responses by stimuli delivered during inspiration, indicating that the inspiratory refractoriness of the vagal mechanisms is not absolute. Biscoe & Sampson (1970) In all four experiments typical heart rate responses were evoked as we have described, and in two there were active inspiratory and expiratory responses to the chemoreceptor stimuli. Black & Torrance (1971) found that brief chemoreceptor stimuli effectively increase ventilation if delivered in inspiration.…”

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confidence: 99%

Baroreceptor and chemoreceptor influences on heart rate during the respiratory cycle in the dog.

Haymet¹,

McCloskey²

1975

The Journal of Physiology

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SUMMARY1. Brief stimuli were delivered to the carotid chemoreceptors or baroreceptors in dogs anaesthetized with pentobarbitone or chloralose. Chemoreceptor stimulation was achieved by rapid retrograde injections of 0-2-05 ml. warmed, CO2-equilibrated saline through a cannula in the external carotid artery. Baroreceptor stimulation was achieved by forceful retrograde injection of 2-5 ml. air-equilibrated saline, or of freshly drawn arterial blood, into the external carotid artery after first clamping the common carotid artery.2. Brief baroreceptor stimuli had no noticeable effect on breathing. Brief chemoreceptor stimuli had no effect on breathing in some dogs, but in many produced a reflex increase in the depth of inspiration when delivered during inspiration. In these same dogs, brief chemoreceptor stimuli delivered in expiration either prolonged the expiratory pause or evoked an active expiratory effort.3. Prompt decreases in heart rate were elicited by brief sudden chemoreceptor or baroreceptor stimuli when these were delivered during the expiratory phase of respiration. The stimuli did not modify the control heart rate pattern when delivered during inspiration. If the carotid sinus nerve or the vagus nerves were cut the responses were abolished. 4. Brief chemoreceptor or baroreceptor stimuli remained effective in evoking prompt decreases in heart rate during periods of apnoea in the end-inspiratory position (Hering-Breuer inflation reflex). In periods of apnoea after prolonged artificial hyperventilation the stimuli were sometimes ineffective at first, but were always effective late in the period of apnoea, again producing prompt cardiac slowing.5. After denervation of the lungs, brief baroreceptor and chemoreceptor stimuli continued to evoke prompt falls in heart rate when given during B. T. HAYMET AND D. I. McCLOSKEY expiration. When delivered during inspiration the same stimuli were either ineffective, or less effective.

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An analysis of the inhibition of phrenic motoneurones which occurs on stimulation of some cranial nerve afferents

Cited by 56 publications

References 16 publications

Stereotyped phrenic response to laryngeal afferent volleys: The mechanism and anesthetic sensitivity.

Stereotyped phrenic response to laryngeal afferent volleys: The mechanism and anesthetic sensitivity.

Extra‐segmental reflexes derived from intercostal afferents: phrenic and laryngeal responses

Baroreceptor and chemoreceptor influences on heart rate during the respiratory cycle in the dog.

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