An analysis of the morbidity associated with abdominal wall resection and reconstruction after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC)

Parikh, Roneil; Shah, Sanjana; Dhurandhar, Vikrant; Alzahrani, Nayef; Fisher, Oliver M.; Arrowaili, Arief; Morris, David L.

doi:10.1016/j.ejso.2018.12.020

Cited by 7 publications

(12 citation statements)

References 33 publications

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“…Our search yielded ninety four articles of which nine studies were selected for data extraction [ 10 , 19 – 21 , 32 – 34 , 44 ]. Studies selected were published between 2014 and 2023, conducted in six countries.…”

Section: Resultsmentioning

confidence: 99%

“…All but one study took place at a single institution [ 33 ]. One study did not specify its location but collected data from a prospectively maintained database [ 32 ]. Eight studies included patients who underwent both CRS and HIPEC.…”

Section: Resultsmentioning

confidence: 99%

“…Pathologies were wide ranging with the majority described as ovarian cancer, peritoneal mesothelioma, colorectal cancer and appendiceal cancer. Three studies included recurrent disease [ 10 , 20 , 32 ]. Spencer et al and Wong et al reported on ovarian cancer and mesothelioma in isolation, respectively [ 33 , 34 ].…”

Section: Resultsmentioning

confidence: 99%

“…Where differing closure types within the same study without mesh were utilized these results were pooled into the same analysis. Only one included study reported mesh use and as such this mesh cohort was excluded from the meta-analysis [ 32 ]. One study included a small cohort (5% of patients) whom received “intraperitoneal chemotherapy” with 95% of patients not receiving any.…”

Section: Methodsmentioning

confidence: 99%

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Incisional hernias post cytoreductive surgery/peritonectomy and hyperthermic intraperitoneal chemotherapy: a systematic review and meta-analysis

Mac Curtain,

Qian,

Temperley

et al. 2023

Hernia

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Purpose Cytoreductive surgery (CRS) is often combined with hyperthermic intraperitoneal chemotherapy (HIPEC) for the treatment of peritoneal tumour deposits. Considering CRS, the evidence relating the large incisions, local chemotherapy and abdominal wall trauma to incisional hernias (IH) has not been synthesized. This systematic review and meta-analysis was conducted to examine the proportion of IH present in patients post CRS and the effect HIPEC had on these rates. Methods PubMed, EMBASE, and Cochrane Central Registry of Trials were searched up to June 2023 to examine studies relating IH and CRS plus or minus HIPEC. The most up to date PRISMA guidelines were followed. Pertinent clinical information was synthesized in tabular form. A meta-analysis reporting the pooled proportions of IH post CRS plus or minus HIPEC, the odds of IH in HIPEC versus non-HIPEC CRS and the difference in follow-up time between groups was conducted. Results Nine studies comprising 1416 patients were included. The pooled proportion of IH post CRS was 12% (95% confidence interval (CI) 8–16%) in HIPEC and 7% (95% CI 4–10%) in non-HIPEC patients and 11% (95% CI 7–14%) overall. Previously reported rates of IH in midline laparotomy range from 10 to 30%. The odds of IH in the HIPEC was 1.9 times higher compared to non-HIPEC cohorts however this was not statistically significant (odds ratio (OR) 1.9, 95% 0.7–5.2; p = 0.21). There was no significant difference in average follow-up times between HIPEC and non-HIPEC cohorts. Conclusions IH post CRS plus or minus HIPEC were in the expected range for midline laparotomies. IH in patients receiving HIPEC may occur at a greater proportion than in non-HIPEC patients, however, there were too few studies in our meta-analysis to determine this with statistical significance.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Incisional hernias post cytoreductive surgery/peritonectomy and hyperthermic intraperitoneal chemotherapy: a systematic review and meta-analysis

Mac Curtain,

Qian,

Temperley

et al. 2023

Hernia

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“…4,5 Today, this treatment is successfully used in the treatment modality of colo-rectal, appendix, ovarian, mesothelioma, and gastric cancers. [6][7][8][9] Th e purpose of CRS and HIPEC treatment is to remove the tumors in the intra-abdominal organs and peritoneum (Complete cytoreduction) and then to give heated chemotherapy into the abdomen. 4,9,10 In this treatment, multiple organ resections may be required due to the involvement of the organs with the tumor.…”

Section: Introductionmentioning

confidence: 99%

Peritoneal karsinomatoz için komplet sitoredüksiyon yapılan hastalarda erken morbidite ve mortaliteyi etkileyen faktörler

OZGUN¹,

Öter

Çolakoğlu

et al. 2022

Sakarya Medical Journal

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Amaç: Sitoredüktif cerrahi ve hipertermik intraperitoneal kemoterapi uygulaması, peritoneal karsinomatoz tedavisinde seçilmiş hastalarda kullanılan kombine tedavi yöntemidir. Materyal ve Methot: Çalışmamızda orijini farklı tümörlerin peritoneal metastazlarına bağlı olarak Sitoredüktif Cerrahi ve hipertermik intraperitoneal kemoterapi uygulanan hastalarda erken komplikasyonların gelişimini ve komplikasyonların erken evrelerini etkileyen faktörleri araştırdık. Hastanemizde 2014-2019 yılları arasında periton metastazı nedeniyle ameliyat edilen 76 hastanın tıbbi kayıtları retrospektif olarak değerlendirildi. Çalışmaya sadece tam sitoredüksiyon (CC/0) uygulanan 61 hasta dahil edildi. Bulgular: Periton Kanseri İndeksi (PKİ) ve operasyon süresinin majör komplikasyon gelişimi için bağımsız risk faktörleri olduğu bulundu. Majör komplikasyon gelişimi açısından ameliyat süresi 7 saat ve Periton Kanseri İndeksi kesme değeri sırasıyla 10 saat olarak bulundu. Sonuç: Çalışmamızda, CC/0 uygulanan hastalarda PKİ'nin ondan fazla olması ve ameliyat süresinin 7 saatten fazla sürmesinin majör komplikasyonları ve mortaliteyi artıran neden olduğunu gösterdik. CC / 0 rezeksiyonu yapmak için her türlü çaba gösterilmelidir, ancak PKG'si 10'un üzerinde olan hastalarda ve operasyon süresini 7 saatin üzerine uzatırken daha fazla özen gösterilmelidir. Bu hastalarda postoperatif komplikasyonlar perioperatif mortaliteyi artırarak erken rekürrens ve kısa sağkalıma neden olur.

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Sigmoid colon adenocarcinoma local relapse on abdominal wall. Oncological resection and complex abdominal wall reconstruction

Gil-Catalán

Segura-Sampedro

Jeri-McFarlane

et al. 2022

Cirugía Española (English Edition)

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An analysis of the morbidity associated with abdominal wall resection and reconstruction after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC)

Cited by 7 publications

References 33 publications

Incisional hernias post cytoreductive surgery/peritonectomy and hyperthermic intraperitoneal chemotherapy: a systematic review and meta-analysis

Incisional hernias post cytoreductive surgery/peritonectomy and hyperthermic intraperitoneal chemotherapy: a systematic review and meta-analysis

Peritoneal karsinomatoz için komplet sitoredüksiyon yapılan hastalarda erken morbidite ve mortaliteyi etkileyen faktörler

Sigmoid colon adenocarcinoma local relapse on abdominal wall. Oncological resection and complex abdominal wall reconstruction

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