An analysis of the pattern of pregnancy loss in women with recurrent miscarriage

Li, Tin‐Chiu; Iqbal, Tanzeem; Anstie, Barbara; Gillham, Jo; Amer, Saad; Wood, Karen L.; Laird, Susan

doi:10.1016/s0015-0282(02)04207-3

Cited by 47 publications

(28 citation statements)

References 19 publications

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“…In some researches the authors investigated whether ANA and Aptt might play a role in thrombophilia syndromes. In our series ANA was negative in all cases and Aptt values were above the normal range in one case [18]. The delayed growth of the endometrium in luteal deficiency may depend on deficient estrogen levels in the follicular phase or insufficient progesterone production in the luteal phase.…”

Section: Discussionsupporting

confidence: 44%

The Role of Endocrine and Endometrial Factors in Cases of Recurrent Miscarriage: A Tertiary Center Experience

Uysal¹,

Taner²,

Mun³

et al. 2015

Ann Clin Anal Med

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Section: Discussionsupporting

confidence: 44%

The Role of Endocrine and Endometrial Factors in Cases of Recurrent Miscarriage: A Tertiary Center Experience

Uysal¹,

Taner²,

Mun³

et al. 2015

Ann Clin Anal Med

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“…The notion that progesterone-dependent differentiation of the endometrium requires elevated intracellular cAMP levels is being exploited in clinical practice. For instance human menopausal gonadotrophins (hMG) and hCG have been used to treat women with unexplained recurrent miscarriages, although larger controlled trials are required to confirm the efficacy of this approach (Scott & Pattison 2000, Li et al 2002.…”

Section: Hormonal Control Of Decidualization -From Cultured Esc To Thmentioning

confidence: 99%

Cyclic AMP and progesterone receptor cross-talk in human endometrium: a decidualizing affair

Gellersen¹,

Brosens²

2003

Journal of Endocrinology

401

378

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During the menstrual cycle, the ovarian hormones oestradiol and progesterone control the ordered growth and differentiation of uterine cells. This remodelling process is critical for implantation of the developing embryo, the formation of the placenta, and maintenance of pregnancy. Failure of uterine tissues to respond appropriately to ovarian hormone signalling results in defective placentation, associated with a spectrum of pregnancy disorders such as recurrent miscarriages and preeclampsia. These obstetrical disorders are a major cause of maternal and perinatal morbidity and mortality. Progesterone exerts its action on target cells, at least in part, through binding to the progesterone receptor (PR), a member of the steroid/ thyroid hormone receptor superfamily of ligand-activated transcription factors. The mechanism by which progesterone controls the differentiation of human endometrial stromal cells, a process termed decidualization, in the secretory phase of the menstrual cycle is not well understood. Emerging evidence indicates that locally expressed factors and activation of the cAMP second messenger pathway integrate hormonal inputs and confer cellular specificity to progesterone action through the induction of diverse transcription factors capable of modulating PR function.

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“…Recurrent pregnancy loss (RPL) is traditionally defined as three or more consecutive pregnancy losses [1]. Despite this classic definition, detailed work-up is often delayed until the third miscarriage [2].…”

Section: Introductionmentioning

confidence: 99%

Comparison of the accuracy of hysteroscopy and hysterosalpingography in evaluation of the uterine cavity in patients with recurrent pregnancy loss

et al. 2005

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The aim of this study was to compare the accuracy of hysteroscopy and hysterosalpingography (HSG) in evaluating the uterine cavity in patients with recurrent pregnancy loss (RPL). One hundred and twenty consecutive patients with a history of RPL were enrolled into this prospective-observational study in the reproductive endocrinology and infertility clinic of a tertiary referral center. Diagnostic office hysteroscopy without anesthesia or sedation, HSG, and diagnostic laparoscopy when indicated were performed in each case. Eighty-five of 120 (70.83%) hysteroscopic studies performed for RPL demonstrated an acquired (55 cases: 64.7%) or congenital (30 cases: 35.3%) intrauterine lesion. Furthermore, several other etiologic factors were also identified in RPL patients with intrauterine lesions. HSG accurately diagnosed an intrauterine defect in only 56 of 85 (65.88%) cases, based on hysteroscopic confirmation. Fifty percent of the cases with incomplete uterine septum were overlooked during HSG. The sensitivity, specificity, positive predictive value, and negative predictive value of HSG were 74.6%, 79.5%, 90.4%, and 54.7%, respectively. There was a single complication (0.83%) due to hysteroscopy. Hysteroscopy is more accurate than HSG in evaluating the uterine cavity in patients with RPL. We recommend it as a routine procedure instead of HSG.

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An analysis of the pattern of pregnancy loss in women with recurrent miscarriage

Cited by 47 publications

References 19 publications

The Role of Endocrine and Endometrial Factors in Cases of Recurrent Miscarriage: A Tertiary Center Experience

The Role of Endocrine and Endometrial Factors in Cases of Recurrent Miscarriage: A Tertiary Center Experience

Cyclic AMP and progesterone receptor cross-talk in human endometrium: a decidualizing affair

Comparison of the accuracy of hysteroscopy and hysterosalpingography in evaluation of the uterine cavity in patients with recurrent pregnancy loss

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