Epidural catheter placement offers flexibility in block management. However, during epidural catheter insertion, complications such as paresthesias, venous and subarachnoid cannulation, suboptimal catheter placement and coiling of catheter can affect the quality of anesthesia. A prospective randomized controlled study was conducted to assess the effect of priming of epidural space with a single-injection dose of local anesthetic solution (10mL 2% lidocaine+ adrenaline and 10ml 0.5% bupivacaine) before catheter insertion. We randomized 100 patients into 2 equal groups and measured the quality of anesthesia and incidence of catheter related complications. METHODS: A group of 100 patients was randomized and divided in two groups. In Group A [needle group] (n _ 50), local anaesthetic solution was administered through epidural needle before epidural catheter insertion. In Group B [catheter group] (n _ 50), the catheter was inserted immediately after identification of the epidural space. Local anesthetic solution was then injected via the catheter. We noted the occurrence of paresthesia, inability to advance the catheter, or IV or subarachnoid catheter placement, number of attempts to insert catheter. Sensory and motor block were assessed 20 min after the injection of local anesthetic solution. Surgery was initiated when adequate sensory loss was confirmed. Infraumbilical, pelvic general surgeries, hysterectomies and lower limb orthopedic surgeries were included in study. RESULTS: All observations were noted and statistical test of significance was applied. In the catheter group, the incidence of paresthesia during catheter placement was 16% compared with 4% in the needle group (x 2 =4.0, P<0.05). Intravascular catheter placement occurred in 8% versus 0% of patients in the catheter and needle groups, respectively (x 2 = 5.34, P<0.05). The number of attempts to pass catheter was more than one in catheter group as compared to needle group. (x 2 =4.33, P<0.05) More patients in the needle group had excellent quality of surgical conditions than the catheter group (94% versus 35%) (x 2 =9.75, P<0.05). CONCLUSION: We conclude that priming of epidural space with a single injection local anaesthetic dose via the epidural needle before catheter placement improves the quality of anesthetic blockade and reduces catheter-related complications.