An analysis of the relationship between severe iron deficiency anemia and thrombocytopenia

Verma, Vaibhav; Ayalew, Getinet; Sidhu, Gurinder; Ramnaraign, Brian Hemendra; Cutler, J. W.; Khandekar, Sadia; Weedon, Jeremy; Sharma, Geeti; Braverman, Albert S.

doi:10.1007/s00277-014-2199-5

Cited by 11 publications

(6 citation statements)

References 7 publications

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“…Thrombocytopenia is much less common in IDA and is often associated with severe iron deficiency. 3 It has been reported in children (see Table 1 ) and adults. In adults, three studies involving platelet count with IDA were published.…”

Section: Discussionmentioning

confidence: 94%

“…We often see a mild thrombocytosis associated with IDA, 2 which normalizes after iron substitution. A presentation of severe iron deficiency, a mild to severe thrombocytopenia can occasionally be observed, 3 which in general resolved quickly after the start of iron therapy. Rarely the thrombocytopenia presents a few days after the start of iron replacement therapy.…”

Section: Introductionmentioning

confidence: 99%

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Thrombocytopenia in severe iron deficiency anemia in children

Akker

Chielens²,

Lopes

et al. 2021

Health Science Reports

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Aim Iron deficiency anemia (IDA) is common in the pediatric population and often accompanied by mild thrombocytosis, but rarely profound thrombocytopenia is seen. We describe the data of children with IDA and thrombocytopenia in two centers and discuss the published data in the literature. Methods In this retrospective case series, the medical records of patients under the age of 19 years old diagnosed with IDA in two tertiary medical centers over the last 10 years, were reviewed. The data were collected and compared to the data published in the medical literature. Results All the patients presented with severe IDA and thrombocytopenia improved with iron treatment. Although none of the patients had signs of major bleeding, the thrombocytopenia could mostly be classified as severe (platelet count <50×10E9/L). Due to the severity of the anemia, in about half of the cases, a red blood cell transfusion was given. The peak of the platelet count was seen in the first month after the start of iron treatment. In eight cases of children with IDA, the thrombocytopenia appeared after the supplementation of iron was started. Conclusion Clinically stable children with severe IDA and thrombocytopenia, where other causes are very unlikely, warrant an empiric monotherapy with iron to prevent unnecessary investigations and treatments.

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Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Thrombocytopenia in severe iron deficiency anemia in children

Akker

Chielens²,

Lopes

et al. 2021

Health Science Reports

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“…It should be noted, however, that variations of both hepcidin and ferritin levels remained minimal. Thrombocytopenia can be observed in severe iron deficiency, and clinicians should be aware of this rare event (less than 50 reported cases 55,[63][64][65][66] ). It can be falsely diagnosed as an immune thrombocytopenia that can be associated with iron deficiency secondary to bleeding.…”

Section: Absolute Iron Deficiencymentioning

confidence: 99%

Iron and platelets: A subtle, under‐recognized relationship

et al. 2021

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“…The clinical presentation of IDA can be due to three main interacting factors (see Figure 2): menorrhagia, thrombocytopenia and iron deficiency 6,19 . Menorrhagia leads to iron loss and consumption of platelets.…”

Section: Pathophysiology Of Iron Deficiency and Thrombocytopeniamentioning

confidence: 99%

The multifactorial etiology and approach to iron deficiency anemia in adolescent girls

2020

IJCR

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Iron deficiency anemia (IDA) is a common but underdiagnosed cause of morbidity in adolescent females. Associated thrombocytopenia is rare, but resolves when the anemia is treated with iron supplementation. Menorrhagia is an important cause in the multifactorial etiology and may be familial. This article presents a case of severe anemia and thrombocytopenia in the presence of iron deficiency due to menorrhagia. A holistic approach to IDA is discussed with an approach to the management thereof in adolescent females.

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An analysis of the relationship between severe iron deficiency anemia and thrombocytopenia

Cited by 11 publications

References 7 publications

Thrombocytopenia in severe iron deficiency anemia in children

Thrombocytopenia in severe iron deficiency anemia in children

Iron and platelets: A subtle, under‐recognized relationship

The multifactorial etiology and approach to iron deficiency anemia in adolescent girls

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