An Analysis of Thirty Patients Surviving Longer than Ten Years after Treatment for Osteogenic Sarcoma

Prognostic factors in osteosarcoma: A review of 20 years' experience at the university of pittsburgh health center hospitals

“…22 Their findings were later corroborated by O'Hara and associates. 25 Our study also supports the observation that serum alkaline phosphatase determinations are helpful in determining prognosis. We feel that the post-operative followup regimen should consist of serum alkaline phosphatase determinations, chest tomograms, and a yearly technetium bone scan.…”

“…However, O'Hara et al analyzed 30 patients surviving 10 years or longer after treatment for osteosarcoma, and found no particular or lowgrade pattern to warrant subdivision. 25 Several investigators havc attempted to correlate the degree of lymphocytic infiltration of various tumors to patient prognosis. There have been studies in the areas of neuroblastoma, Hodgkin's disease, carcinoma of the breast, and gastric and colonic carcinoma^.^*^^'^ Some authors have attributed a lymphocytic infiltration of osteosarcomas as evidence than an intact host immune system is resisting the "common sarcoma antigen.…”

Influence of extracorporeal irradiation on the reintegration of autologous grafts of bone and joint

“…The rate of survival of patients with primary malignant bone tumours has improved from less than 20% [1][2][3] to approximately 80%, [4][5][6][7] mainly as a result of advances in imaging and chemotherapy. 8 Modern protocols of multidisciplinary treatment with limb-salvage procedures have similar outcomes to those of previous ablative surgery.…”

The Surgical Treatment and Outcome of Pathological Fractures in Localised Osteosarcoma

“…Preoperative chemotherapy results in shrinkage of the tumour and, occasionally, union of the fracture will occur (Jaffe et al 1987;Dubousset, Missenard and Kalifa 1991;Thompson, Pritchard and Nelson 1992), but the influence of the fracture on the prognosis of patients with osteosarcoma remains uncertain (McKenna et al 1966;O'Hara et al 1968). After a course of preoperative chemotherapy we have used limb salvage or amputation to treat these patients.…”