R&D and innovation activities are among the areas of critical importance for a country's national development and pioneering technological developments. R&D and innovation, which is an important field of study in terms of contributing to the evaluation of technical skills and regional specialization, are concepts that aim to achieve goals such as technological development, creation of new products and services, improvement of existing processes and increase in competitiveness. Accordingly, in this study, which focuses on ranking the R&D and innovation potential of provinces in Turkey, DEMATEL, ARAS and COPRAS methods, which are multi-criteria decision-making methods, were used. The weighting of the 12 criteria was done by DEMATEL method and 81 provinces were ranked by ARAS and COPRAS methods using these weight values. Maps were created according to the scores of the provinces from each method. According to the results obtained, most of the 81 provinces in Turkey showed similar results in both methods. A general evaluation was made according to these results and criteria.