An analytic study on nonlinear radius change for hyperelastic tubular organs under volume expansion

Gou, Kun; Muddamallappa, Mallikarjunaiah S.

doi:10.1007/s00707-019-02603-8

Cited by 7 publications

(2 citation statements)

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“…For tubular organs, internal tissue growth significantly contributes to organ deformations. Usually growth is employed as an input to generate deformations which are then analyzed for normal physiological alterations or organ malfunctions [ 28 , 29 ]. In some physiological activities, however, TOs need to acquire necessary deformations to maintain proper functionality under internal growth [ 18 , 25 , 26 ].…”

Section: Summary and Discussionmentioning

confidence: 99%

“…Growth is particularly recognized as a significant factor initiating TODs that lead to organ spatial structural responses that are adaptive or pathological [18,25,26]. When TODs are initiated partially or fully by growth involving internal volume changes, morphoelasticity is commonly used to illustrate how growth contributes to the total deformation [27][28][29][30]. Induced by growth, soft-tissue organs deform themselves as part of normal physiological operations [31], and specific TODs are generated to achieve particular functional needs of the TOs [32].…”

Section: Introductionmentioning

confidence: 99%

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Growth-profile configuration for specific deformations of tubular organs: A study of growth-induced thinning and dilation of the human cervix

et al. 2021

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Growth is a significant factor that results in deformations of tubular organs, and particular deformations associated with growth enable tubular organs to perform certain physiological functions. Configuring growth profiles that achieve particular deformation patterns is critical for analyzing potential pathological conditions and for developing corresponding clinical treatments for tubular organ dysfunctions. However, deformation-targeted growth is rarely studied. In this article, the human cervix during pregnancy is studied as an example to show how cervical thinning and dilation are generated by growth. An advanced hyperelasticity theory called morphoelasticity is employed to model the deformations, and a growth tensor is used to represent growth in three principle directions. The computational results demonstrate that both negative radial growth and positive circumferential growth facilitate thinning and dilation. Modeling such mixed growth represents an advancement beyond commonly used uniform growth inside tissues to study tubular deformations. The results reveal that complex growth may occur inside tissues to achieve certain tubular deformations. Integration of further biochemical and cellular activities that initiate and mediate such complex growth remains to be explored.

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