For complex working conditions in power grid, it is easy to produce a large number of harmonics, and the double second-order generalized integrator phase-locked loop (DSOGI-PLL) cannot effectively suppress low-order harmonics, a new DSOGI-PLL based on modified sequential cascaded harmonic cancellation module is proposed in this paper. By designing a harmonic cancellation module that eliminates specific frequency harmonics, different frequency harmonic cancellation modules are cascaded in order from small to large to eliminate low frequency harmonics near the basic frequency. By building the simulation model, the comparison analysis verifies that the modified DSOGI-PLL has higher accuracy in tracking the frequency and phase of the voltage signal, and is more suitable for the power grid.