Frequent accidents may happen during the string run-down and pull process due to the lack of accuracy in the prediction of string force analysis. In order to precisely predict the completion string axial force in horizontal wells, a new model is established, and an in-house software has been developed. The model aims to predict the multiple local resistances that occur at different points on the completion string, which makes up for the technical defects of the commonly used software. It can calculate resistance at different points of the string, which will lead to varying hook load amplification. This method can also predict the axial force of the completion string. By changing the hook load, location, and direction, the resistance can be determined more accurately. Based on the calculation and analysis, the relationship between local resistance, the blocking point, and the amplification factor is also obtained. Furthermore, this model is used to analyze the local resistance of a horizontal well with multiple external packers in the low-permeability Sadi Reservoir of Halfaya Oilfield, Iraq. The recorded data from in-site operations are compared with the predicted results from this model. The results show that the relative errors between the recorded data and model calculation are within the range of 10%, which indicates that the calculated values are reliable. Meanwhile, the results indicate the success of the subsequent completion design and the construction of the oilfield.